Funded in part by Innovation Initiative of the Dutch Health Insurance Companies
Impact of acute versus prolonged exercise and dehydration on kidney function and injury
Bongers CCWG, Alsady M, Nijenhuis T, Tulp ADM, Eijsvogels TMH, Deen PMT, Hopman MTE
Physiological reports · 65 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Controlled clinical trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Industry funded
- Government
- Horizon 2020 Framework Programme
- Nonprofit
- Stichting voor de Technische Wetenschappen
- Nonprofit
- Society of Experimental Laboratory Medicine
- Industry group
- Innovation Initiative of the Dutch Health Insurance Companies
- Grants
- Stichting voor de Technische Wetenschappen (12864); Horizon 2020 Framework Programme (655502)
Based on 4 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2018-06-01 · Physiol Rep · vol. 6 · issue 11 · p. e13734
- Publisher
- Wiley
- Cited
- 82 citations · more than 95% of similar papers · 4.3× the field average
- Impact
- Top 10% most cited in its field
- References
- 50 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Thermoregulation and physiological responses · Electrolyte and hormonal disorders · Climate Change and Health Impacts
- Keywords
- Acute kidney injury, Dehydration, Medicine, Renal function, Function (biology), Internal medicine, Intensive care medicine, Chemistry, Biology, Biochemistry
- MeSH
- kidney, humans, dehydration, glomerular filtration rate, exercise, water-electrolyte balance, adolescent, adult, male, young adult, acute kidney injury, biomarkers
7 authors
From NL, GB
- Coen C. W. G. BongersRadboud University Nijmegen; Radboud University Medical Center; Radboud Institute for Molecular Life Sciences
- Mohammad AlsadyRadboud University Nijmegen; Radboud University Medical Center; Radboud Institute for Molecular Life Sciences
- Tom NijenhuisRadboud University Nijmegen; Radboud University Medical Center; Radboud Institute for Molecular Life Sciences
- Anouk D. M. TulpRadboud University Nijmegen; Radboud University Medical Center; Radboud Institute for Molecular Life Sciences
- Thijs M.H. EijsvogelsRadboud University Nijmegen; Radboud University Medical Center; Radboud Institute for Molecular Life Sciences; Liverpool John Moores University
- Peter M.T. DeenRadboud University Nijmegen; Radboud University Medical Center; Radboud Institute for Molecular Life Sciences
Abstract
Exercise and dehydration may be associated with a compromised kidney function and potential signs of kidney injury. However, the kidney responses to exercise of different durations and hypohydration levels are not yet known. Therefore, we aimed to compare the effects of acute versus prolonged exercise and dehydration on estimated glomerular filtration rate (eGFR) and kidney injury biomarkers in healthy male adults. A total of 35 subjects (23 ± 3 years) were included and invited for two study visits. Visit 1 consisted of a maximal cycling test. On Visit 2, subjects performed a submaximal exercise test at 80% of maximal heart rate until 3% hypohydration. Blood and urine samples were taken at baseline, after 30 min of exercise (acute effects; low level of hypohydration) and after 150 min of exercise or when 3% hypohydration was achieved (prolonged effects, high level of hypohydration). Urinary outcome parameters were corrected for urinary cystatin C, creatinine, and osmolality. Subjects dehydrated on average 0.6 ± 0.3% and 2.9 ± 0.7% after acute and prolonged exercise, respectively (P cystatin C did not differ between baseline and acute exercise (118 ± 11 vs. 116 ± 12 mL/min/1.73 m2 , P = 0.12), whereas eGFRcystatin C was significantly lower after prolonged exercise (103 ± 16 mL/min/1.73 m2 , P 0.05), and elevated osmolality corrected uNGAL concentrations after acute and prolonged exercise (all P-values cystatin C and kidney injury biomarkers, whereas prolonged exercise is associated with a decline in eGFRcystatin C and increased biomarkers for kidney injury.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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