Funded in part by GlaxoSmithKline
Strong Relation Between Muscle Mass Determined by D3-creatine Dilution, Physical Performance, and Incidence of Falls and Mobility Limitations in a Prospective Cohort of Older Men
Cawthon PM, Orwoll ES, Peters KE, Ensrud KE, Cauley JA, Kado DM, Stefanick ML, Shikany JM, Strotmeyer ES, Glynn NW, Caserotti P, Shankaran M, Hellerstein M, Cummings SR, Evans WJ, Osteoporotic Fractures in Men (MrOS) Study Research Group
The journals of gerontology. Series A, Biological sciences and medical sciences · 184 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Industry funded
- Company
- GlaxoSmithKline
- Government
- National Institutes of Health
- Government
- National Institute on Aging
- Government
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- Government
- National Center for Advancing Translational Sciences
- Government
- NIAMS NIH HHS
- Government
- NIH Roadmap for Medical Research
- Government
- NIA NIH HHS
- Government
- NCATS NIH HHS
- Grants
- National Institute on Aging (U01AG042168); National Institute of Arthritis and Musculoskeletal and Skin Diseases (U01 AG042145); National Institute of Arthritis and Musculoskeletal and Skin Diseases (U01 AG042140); National Institute on Aging (UL1TR000128); National Center for Advancing Translational Sciences (UL1TR000128); National Institute on Aging (AG042140); National Center for Advancing Translational Sciences (U01 AG042124); National Center for Advancing Translational Sciences (U01 AG042168); National Institute of Arthritis and Musculoskeletal and Skin Diseases (U01 AG042143); National Institute on Aging (AG042139); National Institute on Aging (U01 AG027810, U01 AG042124, U01 AG042139, U01 AG042140, U01 AG042143, U01 AG042145, U01 AG042168, U01 AR066160); National Center for Advancing Translational Sciences (U01AG042145); National Institute of Arthritis and Musculoskeletal and Skin Diseases (U01 AG027810); National Institute of Arthritis and Musculoskeletal and Skin Diseases (UL1 TR000128); National Institute on Aging (AG042168); National Institute on Aging (U01 AG042124); National Center for Advancing Translational Sciences (U01 AG042139); National Institute on Aging (AG042124); National Center for Advancing Translational Sciences (R01 AR065268); National Institute on Aging (AG042145); National Center for Advancing Translational Sciences (U01 AG-042140); National Institute on Aging (U01 AR066160); National Center for Advancing Translational Sciences (U01 AR066160); National Institute of Arthritis and Musculoskeletal and Skin Diseases (U01 AR066160); National Center for Advancing Translational Sciences (U01 AG042143); National Institute on Aging (U01AG042139); National Institute on Aging ((P30AG024827); National Institute on Aging (U01 AG-042140); National Institute on Aging (U01 AG027810); National Institute of Arthritis and Musculoskeletal and Skin Diseases (U01 AG042139); National Center for Advancing Translational Sciences (TR000128); National Institute on Aging (AG027810); National Institute of Arthritis and Musculoskeletal and Skin Diseases (U01 AG042124); National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR066160); National Institute on Aging (R01 AR065268); National Center for Advancing Translational Sciences (U01 AG027810); National Institute on Aging (U01 AG027810, U01 AG042124, U01 AG042139, U01 AG042140, U01 AG042143, U01 AG042145, U01 AG042168, U01 AR066160, and UL1 TR000128); National Institute on Aging (AG042143); National Institute on Aging (U01AG042145); National Institute on Aging (U01 AG042143); National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01 AR065268); National Institutes of Health (AG042168); National Institutes of Health (AG042139); National Institutes of Health (U01 AG042124); National Institutes of Health (AR066160); National Institutes of Health (UL1TR000128); National Institutes of Health (U01 AG042168); National Institutes of Health (AG042140); National Institutes of Health (U01-AG027810); National Institutes of Health (U01 AG042139); National Institutes of Health (U01 AG042145); National Institutes of Health (AG027810); National Institutes of Health (TR000128); National Institutes of Health (U01AR066160); National Institutes of Health (U01 AG042143); National Institutes of Health (AG042124); National Institutes of Health (U01 AG027810, U01 AG042124, U01 AG042139, U01 AG042140, U01 AG042143, U01 AG042145, U01 AG042168, U01 AR066160, and UL1 TR000128.); National Institutes of Health (AG042143); National Institutes of Health (U01 AG042140); National Institutes of Health (AG042145); National Institute of Arthritis and Musculoskeletal and Skin Diseases (U01 AG042168)
Based on 9 listed funder(s).
Publication
- Published
- 2018-06-12 · J Gerontol A Biol Sci Med Sci · vol. 74 · issue 6 · pp. 844–852
- Publisher
- Oxford University Press
- Cited
- 218 citations · more than 99% of similar papers · 11.4× the field average
- Impact
- Top 10% most cited in its field
- References
- 40 works
- Access
- Free to read
- Research areas
- Nutrition and Health in Aging · Balance, Gait, and Falls Prevention · Frailty in Older Adults
- Keywords
- Creatine, Incidence (geometry), Prospective cohort study, Cohort, Medicine, Gerontology, Falls in older adults, Physical medicine and rehabilitation, Environmental health, Physiology, Psychology, Demography, Internal medicine, Injury prevention, Poison control, Mathematics
- MeSH
- muscle, skeletal, humans, deuterium, creatine, absorptiometry, photon, body mass index, hand strength, multivariate analysis, cohort studies, indicator dilution techniques, accidental falls, aged, 80 and over, male, mobility limitation, walking speed, physical functional performance
15 authors
From US, DK
- Peggy Mannen Cawthon · correspondingUniversity of California, San Francisco; California Pacific Medical Center
- ERIC S. ORWOLLOregon Health & Science University
- Katherine E. Peters · correspondingCalifornia Pacific Medical Center
- Kristine E. EnsrudUniversity of Minnesota; Minneapolis VA Health Care System
- Jane A. CauleyUniversity of Pittsburgh
- Deborah M. KadoUniversity of California San Diego
Abstract
Background
Direct assessment of skeletal muscle mass in older adults is clinically challenging. Relationships between lean mass and late-life outcomes have been inconsistent. The D3-creatine dilution method provides a direct assessment of muscle mass.
Methods
Muscle mass was assessed by D3-creatine (D3Cr) dilution in 1,382 men (mean age, 84.2 years). Participants completed the Short Physical Performance Battery (SPPB); usual walking speed (6 m); and dual x-ray absorptiometry (DXA) lean mass. Men self-reported mobility limitations (difficulty walking 2-3 blocks or climbing 10 steps); recurrent falls (2+); and serious injurious falls in the subsequent year. Across quartiles of D3Cr muscle mass/body mass, multivariate linear models calculated means for SPPB and gait speed; multivariate logistic models calculated odds ratios for incident mobility limitations or falls.
Results
Compared to men in the highest quartile, those in the lowest quartile of D3Cr muscle mass/body mass had slower gait speed (Q1: 1.04 vs Q4: 1.17 m/s); lower SPPB (Q1: 8.4 vs Q4: 10.4 points); greater likelihood of incident serious injurious falls (odds ratio [OR] Q1 vs Q4: 2.49, 95% confidence interval [CI]: 1.37, 4.54); prevalent mobility limitation (OR Q1 vs Q4,: 6.1, 95% CI: 3.7, 10.3) and incident mobility limitation (OR Q1 vs Q4: 2.15 95% CI: 1.42, 3.26); p for trend < .001 for all. Results for incident recurrent falls were in the similar direction (p = .156). DXA lean mass had weaker associations with the outcomes.
Conclusions
Unlike DXA lean mass, low D3Cr muscle mass/body mass is strongly related to physical performance, mobility, and incident injurious falls in older men.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.