A Mediterranean-style eating pattern with lean, unprocessed red meat has cardiometabolic benefits for adults who are overweight or obese in a randomized, crossover, controlled feeding trial
O'Connor LE, Paddon-Jones D, Wright AJ, Campbell WW
The American journal of clinical nutrition · 60 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food provided by researchers
Who paid for it
- Funding
- Independent funding
- University or hospital
- Purdue University
- Government
- National Institute of Diabetes and Digestive and Kidney Diseases
- Government
- National Institute of Health's Ingestive Behavior Research Center
- Government
- NIDDK NIH HHS
- Authors
- At least one author declares a financial tie to industry
- Grants
- National Institute of Diabetes and Digestive and Kidney Diseases (T32 DK076540)
Based on 4 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2018-03-23 · Am J Clin Nutr · vol. 108 · issue 1 · pp. 33–40
- Publisher
- Elsevier BV
- Cited
- 76 citations · more than 96% of similar papers · 5.7× the field average
- Impact
- Top 10% most cited in its field
- References
- 43 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Nutritional Studies and Diet · Agriculture Sustainability and Environmental Impact · Dietary Effects on Health
- Keywords
- Red meat, Overweight, Crossover study, Medicine, Body mass index, Blood pressure, Mediterranean diet, Blood lipids, Internal medicine, Placebo, Cholesterol
- MeSH
- humans, cardiovascular diseases, metabolic diseases, body weight, risk factors, cross-over studies, body composition, diet, mediterranean, adult, aged, middle aged, female, male, red meat
4 authors
From US
- Lauren E O’ConnorPurdue University West Lafayette
- Douglas J. Paddon-JonesThe University of Texas Medical Branch at Galveston
- Amy J WrightPurdue University West Lafayette
- Wayne W. Campbell · correspondingPurdue University West Lafayette
Abstract
Background
A Mediterranean-style eating pattern (Mediterranean Pattern) is often described as being low in red meat. Research shows that lean, unprocessed red meat can be incorporated into healthy eating patterns to improve cardiometabolic disease (CMD) risk factors.
Objective
We assessed the effects of consuming different amounts of lean, unprocessed red meat in a Mediterranean Pattern on CMD risk factors. We hypothesized that consuming a Mediterranean Pattern would improve CMD risk factors and that red meat intake would not influence these improvements.
Design
In an investigator-blinded, randomized, crossover, controlled feeding trial, 41 subjects [mean ± SD age: 46 ± 2 y; mean ± SD body mass index (kg/m2): 30.5 ± 0.6] were provided with a Mediterranean Pattern for two 5-wk interventions separated by 4 wk of self-selected eating. The Mediterranean Patterns contained ∼500 g [typical US intake (Med-Red)] and ∼200 g [commonly recommended intake in heart-healthy eating patterns (Med-Control)] of lean, unprocessed beef or pork per week. Red meat intake was compensated by poultry and other protein-rich foods. Baseline and postintervention outcomes included fasting blood pressure, serum lipids, lipoproteins, glucose, insulin, and ambulatory blood pressure. The presented results were adjusted for age, sex, and body mass at each time point (P < 0.05).
Results
Total cholesterol decreased, but greater reductions occurred with Med-Red than with Med-Control (-0.4 ± 0.1 and -0.2 ±0.1 mmol/L, respectively, intervention × time = 0.045]. Low-density lipoprotein decreased with Med-Red but was unchanged with Med-Control [-0.3 ± 0.1 and -0.1 ± 0.1 mmol/L, respectively, intervention × time = 0.038], whereas high-density lipoprotein (HDL) concentrations decreased nondifferentially [-0.1 ± 0.0 mmol/L]. Triglycerides, total cholesterol:HDL, glucose, and insulin did not change with either Med-Red or Med-Control. All blood pressure parameters improved, except during sleep, independent of the red meat intake amount.
Conclusions
Adults who are overweight or moderately obese may improve multiple cardiometabolic disease risk factors by adopting a Mediterranean-style eating pattern with or without reductions in red meat intake when red meats are lean and unprocessed. This trial was registered at clinicaltrials.gov as NCT02573129.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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