Funded in part by American Egg Board/Egg Nutrition Council
Dietary Cholesterol, Lipid Levels, and Cardiovascular Risk among Adults with Diabetes or Impaired Fasting Glucose in the Framingham Offspring Study
Lin HP, Baghdasarian S, Singer MR, Mott MM, Bradlee ML, Pickering RT, Moore LL
Nutrients · 7 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food diaries or recalls
Who paid for it
- Funding
- Industry funded
- Government
- National Institutes of Health
- Government
- National Heart, Lung, and Blood Institute
- Industry group
- American Egg Board/Egg Nutrition Council
- Government
- NHLBI NIH HHS
- Grants
- National Heart, Lung, and Blood Institute (T32HL125232); National Institutes of Health (N01-HC 25195)
Based on 4 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2018-06-14 · Nutrients · vol. 10 · issue 6 · p. 770
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 13 citations · more than 83% of similar papers · 1.5× the field average
- References
- 23 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Nutritional Studies and Diet · Diet and metabolism studies · Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- Medicine, Impaired fasting glucose, Offspring, Internal medicine, Hazard ratio, Cholesterol, Diabetes mellitus, Confounding, Endocrinology, Framingham Heart Study, Type 2 diabetes, Framingham Risk Score, Prospective cohort study, Physiology, Impaired glucose tolerance, Disease, Confidence interval, Biology, Pregnancy
- MeSH
- humans, cardiovascular diseases, diabetes mellitus, type 2, prediabetic state, blood glucose, lipids, cholesterol, dietary, risk factors, sex factors, adult, middle aged, female, cigarette smoking
7 authors
From US
- Hsuan-Ping LinBoston University
- Siyouneh BaghdasarianBoston University
- Martha R. SingerBoston University
- Melanie M. MottBoston University
- M. Loring BradleeBoston University
- Richard Taylor PickeringBoston University
Abstract
Previous recommendations to limit dietary cholesterol intake have been eliminated for most adults. Questions remain about whether dietary cholesterol has adverse cardiovascular effects among individuals with impaired fasting glucose or diabetes (IFG/T2DM). We used data for 993 adults (40.9% female), ages 35⁻<65 years, with prevalent IFG/T2DM in the prospective Framingham Offspring Study to address this question. Dietary cholesterol was assessed using 3-day diet records at exams 3 and 5 and used to classify subjects into sex-specific tertiles of mean cholesterol intake. Outcomes included fasting lipid levels over 20 years and incident cardiovascular disease (CVD). Statistical analyses included repeated measures mixed regression models and Cox proportional hazards models to adjust for confounding. Among adults with T2DM/IFG, there was no consistent association between dietary cholesterol intake and fasting low-density lipoprotein (LDL), high-density lipoprotein (HDL), LDL/HDL ratio, or triglycerides over 20 years of follow-up. In longitudinal analyses, the adjusted hazard ratio for CVD in the highest (vs. lowest) sex-specific tertile of cholesterol intake was 0.61 (95% CI: 0.41, 0.90). These analyses provide no evidence of an adverse association between dietary cholesterol and serum lipid levels or atherosclerotic CVD risk among adults with prevalent IFG/T2DM.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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