Evaluating the effect of magnesium supplementation and cardiac arrhythmias after acute coronary syndrome: a systematic review and meta-analysis
Salaminia S, Sayehmiri F, Angha P, Sayehmiri K, Motedayen M
BMC cardiovascular disorders · 29 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2018-06-28 · BMC Cardiovasc Disord · vol. 18 · issue 1 · p. 129
- Publisher
- BioMed Central
- Cited
- 48 citations · more than 68% of similar papers · 1.0× the field average
- References
- 48 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Magnesium in Health and Disease · Atrial Fibrillation Management and Outcomes · Potassium and Related Disorders
- Keywords
- Medicine, Meta-analysis, Internal medicine, Placebo, Cardiology, Cardiac surgery, Randomized controlled trial, Publication bias, Odds ratio, Incidence (geometry), Cochrane Library, Angiology, Subgroup analysis
- MeSH
- humans, magnesium sulfate, anti-arrhythmia agents, treatment outcome, incidence, risk factors, adult, aged, middle aged, female, male, arrhythmias, cardiac, acute coronary syndrome, percutaneous coronary intervention, protective factors
5 authors
From IR
- Shirvan SalaminiaYasuj University of Medical Sciences
- Fatemeh SayehmiriShahid Beheshti University of Medical Sciences
- Parvin AnghaYasuj University of Medical Sciences
- Kourosh SayehmiriMedical University of Ilam; Ilam University
- Morteza Motedayen · correspondingZanjan University of Medical Sciences
Abstract
Background
Atrial and ventricular cardiac arrhythmias are one of the most common early complications after cardiac surgery and these serve as a major cause of mortality and morbidity after cardiac revascularization. We want to evaluate the effect of magnesium sulfate administration on the incidence of cardiac arrhythmias after cardiac revascularization by doing this systematic review and meta-analysis.
Methods
The search performed in several databases (SID, Magiran, IranDoc, IranMedex, MedLib, PubMed, EmBase, Web of Science, Scopus, the Cochrane Library and Google Scholar) for published Randomized controlled trials before December 2017 that have reported the association between Magnesium consumption and the incidence of cardiac arrhythmias. This relationship measured using odds ratios (ORs) with a confidence interval of 95% (CIs). Funnel plots and Egger test used to examine publication bias. STATA (version 11.1) used for all analyses.
Results
Twenty-two studies selected as eligible for this research and included in the final analysis. The total rate of ventricular arrhythmia was lower in the group receiving magnesium sulfate than placebo (11.88% versus 24.24%). The same trend obtained for the total incidence of supraventricular arrhythmia (10.36% in the magnesium versus 23.91% in the placebo group). In general the present meta-analysis showed that magnesium could decrease ventricular and supraventricular arrhythmias compared with placebo (OR = 0.32, 95% CI 0.16-0.49; p < 0.001 and OR = 0.42, 95% CI 0.22-0.65; p < 0.001, respectively). Subgroup analysis showed that the effect of magnesium on the incidence of cardiac arrhythmias was not affected by clinical settings and dosage of magnesium. Meta-regression analysis also showed that there was no significant association between the reduction of ventricular arrhythmias and sample size.
Conclusion
The results of this meta-analysis study suggest that magnesium sulfate can be used safely and effectively and is a cost-effective way in the prevention of many of ventricular and supraventricular arrhythmias.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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