Implications of standardization of serum 25-hydroxyvitamin D data for the evaluation of vitamin D status in Germany, including a temporal analysis
Rabenberg M, Scheidt-Nave C, Busch MA, Thamm M, Rieckmann N, Durazo-Arvizu RA, Dowling KG, Škrabáková Z, Cashman KD, Sempos CT, Mensink GBM
BMC public health · 49 citations
How it was studied
- Design
- Cross-sectional study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- Bundesministerium für Bildung und Forschung
- Government
- Bundesministerium für Gesundheit
- Government
- Bundesministerium für Ernährung und Landwirtschaft
Based on 3 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2018-07-06 · BMC Public Health · vol. 18 · issue 1 · p. 845
- Publisher
- BioMed Central
- Cited
- 76 citations · more than 97% of similar papers · 5.4× the field average
- Impact
- Top 10% most cited in its field
- References
- 47 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Vitamin D Research Studies · Nutrition, Genetics, and Disease · Nutritional Studies and Diet
- Keywords
- Medicine, Biostatistics, Standardization, Vitamin D and neurology, Epidemiology, vitamin D deficiency, Public health, Calcifediol, Environmental health, Gerontology, Internal medicine, Pathology
- MeSH
- humans, vitamin d deficiency, vitamin d, health surveys, prevalence, retrospective studies, reference standards, adolescent, adult, aged, middle aged, child, child, preschool, infant, germany, female, male, young adult
11 authors
From DE, US, IE
- Martina Rabenberg · correspondingRobert Koch Institute
- Christa Scheidt‐NaveRobert Koch Institute
- Markus Alexander BuschRobert Koch Institute
- Michael ThammRobert Koch Institute
- Nina RieckmannBerlin Institute of Health at Charité - Universitätsmedizin Berlin; Charité - Universitätsmedizin Berlin
- Ramón Durazo-ArvizúLoyola University Chicago
Abstract
Background
Comparability of 25-hydroxyvitamin D (25(OH)D) measurements is hampered by method-related differences in measurement values. International standardization of laboratory assays has been suggested to solve this problem.
Methods
As part of the European Commission-funded project 'Food-based solutions for optimal vitamin D nutrition and health through the life cycle' (ODIN), original measurements of serum 25(OH)D of three German national health surveys conducted between 1998 and 2011 have been standardized retrospectively. In these representative population-based samples including persons aged between 1 and 79 years, the original 25(OH)D values were compared with those after standardization. Mean values and prevalences of vitamin D deficiency, insufficiency, and sufficiency (25(OH)D levels =50 nmol/l, respectively) were calculated by sex and age groups based on original and standardized 25(OH)D data.
Results
In comparison to the original 25(OH)D levels, the standardized levels showed higher means overall and in age- and sex-specific analyses. After standardization, the prevalence of vitamin D deficiency was lower in all surveys while the prevalence of vitamin D sufficiency was higher. Nevertheless, even after standardization ~ 15% of adults and 12.5% of children had serum 25(OH)D levels < 30 nmol/l. Thus, the proportion of deficient vitamin D levels in the German population is still considerable.
Conclusions
The use of standardization of 25(OH)D levels has a substantial impact on estimates of the vitamin D status in Germany. Since clinical diagnostic, therapeutic and public health decision-making require valid and comparable data, standardization and calibration of commercial, clinical and research laboratory assays for 25(OH)D measurement should become common practice. Until then, researchers, health practitioners and policy makers should be aware of the peculiarities of the measurement methods when comparing and interpreting 25(OH)D levels.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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