The Effects of Music Therapy on Cognition, Psychiatric Symptoms, and Activities of Daily Living in Patients with Alzheimer's Disease
Lyu J, Zhang J, Mu H, Li W, Champ M, Xiong Q, Gao T, Xie L, Jin W, Yang W, Cui M, Gao M, Li M
Journal of Alzheimer's disease : JAD · 100 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- Beijing Municipal Administration of Hospitals
Based on 1 listed funder(s).
Publication
- Published
- 2018-07-06 · J Alzheimers Dis · vol. 64 · issue 4 · pp. 1347–1358
- Publisher
- IOS Press
- Cited
- 156 citations · more than 98% of similar papers · 7.7× the field average
- Impact
- Top 10% most cited in its field
- References
- 33 works
- Access
- Open access (repository copy)
- Research areas
- Music Therapy and Health · Dementia and Cognitive Impairment Research · Neuroscience and Music Perception
- Keywords
- Music therapy, Disease, Cognition, Activities of daily living, Alzheimer's disease, Psychology, Psychiatry, Medicine, Psychotherapist, Clinical psychology, Internal medicine
- MeSH
- humans, alzheimer disease, treatment outcome, music therapy, activities of daily living, statistics, nonparametric, retrospective studies, mental recall, verbal learning, cognition disorders, psychiatric status rating scales, neuropsychological tests, aged, middle aged, female, male
13 authors
From CN, GB
- Jihui Lyu · correspondingCapital Medical University; Beijing Geriatric Hospital; Chinese Institute for Brain Research; Beijing Institute for Brain Disorders
- Jingnan ZhangCapital Medical University; Chinese Institute for Brain Research; Beijing Institute for Brain Disorders
- Haiyan MuBeijing Geriatric Hospital
- Wenjie LiBeijing Geriatric Hospital
- Mei ChampUniversity of the West of England
- Qian XiongLancaster University
Abstract
Background
Alzheimer's disease (AD) is the most common type of dementia, affecting millions of older people worldwide. However, pharmacological therapies have not achieved desirable clinical efficacy in the past decades. Non-pharmacological therapies have been receiving increased attention to treat dementia in recent years.
Objective
This study explores the effects of music therapy on cognitive function and mental wellbeing of patients with AD.
Methods
A total number of 298 AD patients with mild, moderate, or severe dementia participated in the study. The participants with each grade of severity were randomly divided into three groups, which were a singing group, a lyric reading group, and a control group. These three groups received different interventions for three months. All participants underwent a series of tests on cognitive functions, neuropsychological symptoms, and activities of daily living at baseline, three months, and six months.
Results
The analysis shows that music therapy is more effective for improving verbal fluency and for alleviating the psychiatric symptoms and caregiver distress than lyrics reading in patients with AD. Stratified analysis shows that music therapy is effective for enhancing memory and language ability in patients with mild AD and reducing the psychiatric symptoms and caregiver distress in patients with moderate or severe AD. However, no significant effect was found for activities of daily living in patients with mild, moderate, or severe AD.
Conclusion
This study suggests that music therapy is effective in enhancing cognitive function and mental wellbeing and can be recommended as an alternative approach to manage AD associated symptoms.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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