Effect of magnesium supplements on serum C-reactive protein: a systematic review and meta-analysis
Mazidi M, Rezaie P, Banach M
Archives of medical science : AMS · 61 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Meta-analysis (classified by our AI screen)
- Studied in
- People
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Independent funding
- University or hospital
- Chinese Academy of Sciences
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2018-01-01 · Arch Med Sci · vol. 14 · issue 4 · pp. 707–716
- Publisher
- Termedia Publishing House
- Cited
- 80 citations · more than 70% of similar papers · 1.2× the field average
- References
- 52 works
- Access
- Open access (journal) · CC-BY-NC-SA
- Research areas
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Therapeutic Uses of Natural Elements
- Keywords
- Medicine, Meta-analysis, Internal medicine, Randomized controlled trial, Random effects model, C-reactive protein, Study heterogeneity, Gastroenterology, Inflammation
3 authors
From CN, IR, PL
- Mohsen MazidiChinese Academy of Sciences; Institute of Genetics and Developmental Biology
- Peyman RezaieMashhad University of Medical Sciences
- Maciej BanachMedical University of Lodz; Polish Mother’s Memorial Hospital Research Institute; University of Zielona Góra
Abstract
Introduction
The aim of the study was to undertake a systematic review and meta-analysis of prospective studies to determine the effect of magnesium (Mg) supplementation on C-reactive protein (CRP). Design: Systematic review and meta-analysis of randomised controlled trials (RCTs).
Material and methods
Data sources: PubMed-Medline, Web of Science, Cochrane Database, and Google Scholar databases were searched (up until December 2016). Eligibility criteria: Randomized controlled trials evaluating the impact of Mg supplementation on CRP. We used random effects models meta-analysis for quantitative data synthesis. For sensitivity analysis was used the leave-one-out method. Heterogeneity was quantitatively assessed using the I2 index. Main outcome: Level of CRP after Mg supplementation.
Results
From a total of 96 entries identified via searches, eight studies were included in the final selection. The meta-analysis indicated a significant reduction in serum CRP concentrations following Mg supplementation (weighted mean difference (WMD) -1.33 mg/l; 95% CI: -2.63 to -0.02, heterogeneity p I2 = 29.1%). The WMD for interleukin 6 was -0.16 pg/dl (95% CI: -3.52 to 3.26, heterogeneity p = 0.802; I2 = 2.3%), and 0.61 mg/dl (95% CI: -2.72 to 1.48, p = 0.182, heterogeneity p = 0.742; I2 = 6.1%) for fasting blood glucose. These findings were robust in sensitivity analyses. Random-effects meta-regression revealed that changes in serum CRP levels were independent of the dosage of Mg supplementation (slope: -0.004; 95% CI: -0.03, 0.02; p = 0.720) or duration of follow-up (slope: -0.06; 95% CI: -0.37, 0.24; p = 0.681).
Conclusions
This meta-analysis suggests that Mg supplementation significantly reduces serum CRP level. RCTs with a larger sample size and a longer follow-up period should be considered for future investigations to give an unequivocal answer.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-SA).
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