Magnesium Supplementation and Blood Pressure in Pregnancy: A Double-Blind Randomized Multicenter Study
Bullarbo M, Mattson H, Broman AK, Ödman N, Nielsen TF
Journal of pregnancy · 16 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- Research and Development Foundation at Region Halland and Södra Älvsborg
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2018-05-29 · J Pregnancy · vol. 2018 · pp. 1–10
- Publisher
- Hindawi Publishing Corporation
- Cited
- 22 citations · more than 86% of similar papers · 1.9× the field average
- References
- 36 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Pregnancy and preeclampsia studies · Magnesium in Health and Disease · Birth, Development, and Health
- Keywords
- Medicine, Blood pressure, Placebo, Randomized controlled trial, Pregnancy, Magnesium, Multicenter study, Obstetrics, Internal medicine
- MeSH
- humans, hypertension, pregnancy-induced, birth weight, magnesium, delivery, obstetric, double-blind method, pregnancy, dietary supplements, adult, infant, newborn, female, young adult
5 authors
From SE
- Maria Bullarbo · correspondingUniversity of Gothenburg
- Helena MattsonSödra Älvsborg Hospital
- Anna‐Karin BromanNorra Älvsborgs Länssjukhus
- Natalia ÖdmanSödra Älvsborg Hospital
- Thorkild F. NielsenUniversity of Gothenburg
Abstract
Objective
To investigate the effect of magnesium (Mg) supplementation in healthy pregnant women for prevention of blood pressure increase. Secondary outcomes were comparison of biomarkers for hypertensive disorders and labour and fetal outcomes between the groups.
Methods
Two hundred nulliparous healthy pregnant women were double-blind randomized to receive Mg daily or placebo.
Results
There were no differences in blood pressure increase. However, among the Mg-treated women, there was a significant negative correlation between increase in blood levels of magnesium and increase in systolic blood pressure (p = 0.042). Magnesium supplementation seems to be safe for both mother and infant.
Conclusion
Magnesium supplementation in healthy first-time pregnant women is not to be recommended for prevention of blood pressure increase. Supplementation in risk pregnancies needs to be further investigated. The study is listed on the ISRCTN registry with study ID 13890849.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.