Association between Blood 25-Hydroxyvitamin D Levels and Survival in Colorectal Cancer Patients: An Updated Systematic Review and Meta-Analysis
Maalmi H, Walter V, Jansen L, Boakye D, Schöttker B, Hoffmeister M, Brenner H
Nutrients · 61 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Possibly industry funded
- Company
- Klaus Tschira Stiftung
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2018-07-13 · Nutrients · vol. 10 · issue 7 · p. 896
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 97 citations · more than 94% of similar papers · 3.1× the field average
- Impact
- Top 10% most cited in its field
- References
- 40 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Vitamin D Research Studies · Bone health and osteoporosis research · Parathyroid Disorders and Treatments
- Keywords
- Meta-analysis, Colorectal cancer, Medicine, Hazard ratio, Internal medicine, Subgroup analysis, Confidence interval, Vitamin D and neurology, Oncology, Sample size determination, Publication bias, Randomized controlled trial, Web of science, Cancer
- MeSH
- humans, colorectal neoplasms, vitamin d deficiency, disease progression, vitamin d, neoplasm staging, disease-free survival, treatment outcome, risk factors, time factors, adult, aged, aged, 80 and over, middle aged, female, male, protective factors
7 authors
From DE
- Haïfa MaalmiGerman Cancer Research Center; Heidelberg University
- Viola WalterGerman Cancer Research Center; Heidelberg University
- Lina JansenGerman Cancer Research Center; Heidelberg University
- Daniel BoakyeGerman Cancer Research Center; Heidelberg University
- Ben SchöttkerGerman Cancer Research Center; Heidelberg University
- Michael HoffmeisterGerman Cancer Research Center; Heidelberg University
Abstract
Previous meta-analyses have shown an improved survival with higher blood 25-hydroxyvitamin D (25(OH)D) concentrations in patients with colorectal cancer (CRC). However, a number of much larger studies have been published since then. We provide an updated meta-analysis to synthesize current evidence. PubMed and Web of Science databases were systematically searched for eligible studies. The dose-response relationships and pooled hazard ratios for overall and CRC-specific survival comparing the highest versus the lowest categories of blood 25(OH)D concentrations were assessed. Subgroup analyses based on study geographic location, year of publication, sample size, length of follow-up time and stage were conducted to explore potential sources of heterogeneity. Overall, 11 original studies with a total of 7718 CRC patients were included. The dose-response meta-analysis showed an improvement in survival outcomes with increasing blood 25(OH)D concentrations. Pooled hazard ratios (95% confidence intervals) comparing highest versus lowest categories were 0.68 (0.55⁻0.85) and 0.67 (0.57⁻0.78) for overall and CRC-specific survival, respectively. Associations were more prominent among studies conducted in Europe, with larger sample sizes, and including stage I⁻IV patients. This updated meta-analysis reveals robust evidence of an association between higher blood 25(OH)D concentrations and better survival in CRC patients. The potential for enhancing prognosis of CRC patients by vitamin D supplementation should be explored by randomized trials.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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