Vitamin D receptor gene polymorphism, serum 25-hydroxyvitamin D levels, and risk of vitiligo: A meta-analysis
Zhang JZ, Wang M, Ding Y, Gao F, Feng YY, Yakeya B, Wang P, Wu XJ, Hu FX, Xian J, Kang XJ
Medicine · 28 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2018-07-01 · Medicine (Baltimore) · vol. 97 · issue 29 · p. e11506
- Publisher
- Wolters Kluwer
- Cited
- 41 citations · more than 86% of similar papers · 2.1× the field average
- References
- 47 works
- Access
- Open access (journal) · CC-BY-NC-ND
- Research areas
- melanin and skin pigmentation · Vitamin D Research Studies · Acne and Rosacea Treatments and Effects
- Keywords
- FokI, Vitiligo, TaqI, Medicine, Calcitriol receptor, Internal medicine, Meta-analysis, Odds ratio, Vitamin D and neurology, Gastroenterology, Incidence (geometry), Cochrane Library, vitamin D deficiency, Allele, Endocrinology, Polymorphism (computer science), Immunology, Genetics, Gene, Biology
- MeSH
- humans, vitiligo, vitamin d deficiency, genetic predisposition to disease, vitamin d, receptors, calcitriol, risk factors, genotype, polymorphism, genetic
11 authors
From CN
- Jing-Zhan ZhangPeople's Hospital of Xinjiang Uygur Autonomous Region
- Man Wang
- Yuan Ding
- Feng Gao
- Yanyan Feng
- Buwajieer Yakeya
Abstract
Objectives
To explore the relationship among the vitamin D receptor (VDR) gene polymorphisms, serum 25-hydroxyvitamin D levels, and vitiligo.
Methods
Databases including PubMed, Cochrane Library, Ovid, Web of Science, CNKI, SinoMed, and Wanfang Data were systematically searched. The association was assessed using odds ratios (ORs), standard mean difference (SMD), and 95% confidence intervals (CIs). The statistical tests were performed using Review Manager 5.3.3.
Results
We identified a total of 17 studies. The relationship between VDR gene polymorphisms (BsmI, ApaI, TaqI, and FokI), serum 25 (OH)D levels, and incidence of vitiligo was investigated. The results of this meta-analysis showed that the dominant genetic model (CC+AC vs AA, P = .007, OR = 1.41, 95% CI = 1.10-1.80), recessive genetic model (CC vs AC+AA, P = .01, OR = 4.10, 95% CI = 1.36-12.35), and allelic contrast model (C vs A, P = .005, OR = 1.87, 95% CI = 1.21-2.90) of VDR Apal locus increased the risk of vitiligo, and BsmI, TaqI, and FokI loci and the risk of vitiligo have no obvious correlation. Serum 25 (OH)D deficiency was positively associated with the incidence of vitiligo (P < .0001, SMD = -0.94, 95% CI = -1.39, -0.48).
Conclusion
This meta-analysis revealed that VDR Apal polymorphism increased the susceptibility risk of vitiligo, and there is a positive correlation between serum 25 (OH)D deficiency and the incidence of vitiligo.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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