Multiple Cold-Water Immersions Attenuate Muscle Damage but not Alter Systemic Inflammation and Muscle Function Recovery: A Parallel Randomized Controlled Trial
Siqueira AF, Vieira A, Bottaro M, Ferreira-Júnior JB, Nóbrega OT, de Souza VC, Marqueti RC, Babault N, Durigan JLQ
Scientific reports · 39 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- University or hospital
- Heinrich-Heine-Universität Düsseldorf
- Government
- Ministério da Ciência, Tecnologia e Inovação
- Government
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Government
- Ministry of Science, Technology and Innovation | Conselho Nacional de Desenvolvimento Científico e Tecnológico (National Council for Scientific and Technological Development)
- Government
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Brazilian Federal Agency for the Support and Evaluation of Graduate Education)
- Grants
- Ministério da Ciência, Tecnologia e Inovação (BEX 5191/14-9); Ministério da Ciência, Tecnologia e Inovação (401453/2013-8); Conselho Nacional de Desenvolvimento Científico e Tecnológico (2013-8); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (401453/2013-8); Conselho Nacional de Desenvolvimento Científico e Tecnológico (-8 and); Conselho Nacional de Desenvolvimento Científico e Tecnológico (310359/2014-7); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (BEX 5191/14-9)
Based on 6 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2018-07-13 · Sci Rep · vol. 8 · issue 1 · p. 10961
- Publisher
- Nature Portfolio
- Cited
- 54 citations · more than 92% of similar papers · 3.2× the field average
- Impact
- Top 10% most cited in its field
- References
- 65 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Exercise and Physiological Responses · Sports injuries and prevention · Cardiovascular and exercise physiology
- Keywords
- Muscle damage, Creatine kinase, Medicine, Inflammation, Delayed onset muscle soreness, Cryotherapy, Systemic inflammation, Internal medicine, Randomized controlled trial, Endocrinology, Surgery
- MeSH
- muscle, skeletal, extracellular matrix, humans, creatine kinase, c-reactive protein, cytokines, cryotherapy, recovery of function, male, matrix metalloproteinase 3, muscle strength, young adult, myalgia
9 authors
From BR, US, FR
- Angelina Freitas SiqueiraUniversidade de Brasília
- Amilton VieiraCentro Universitário do Distrito Federal
- Martim BottaroUniversidade de Brasília
- João B. Ferreira‐JúniorInstituto Federal do Sudeste de Minas Gerais
- Otávio de Tolêdo NóbregaUniversidade de Brasília; Brescia University
- Vinícius Carolino SouzaUniversidade de Brasília; Brescia University
Abstract
The aim of this study was to investigate the effects of multiple cold-water immersions (CWIs) on muscle function, markers of muscle damage, systemic inflammation and ECM degradation following exercise-induced muscle damage (EIMD). Thirty physically active males were randomly assigned to either a control (n = 15) or cold-water immersion (CWI) group (n = 15). The CWI group performed one immersion (10 °C for 20 min) at post-exercise and every 24 h for the following 72 h, while the control group remained in a seated position during these corresponding periods. Muscle strength, vertical jump height, muscle thickness, delayed-onset muscle soreness (DOMS), systemic creatine kinase (CK), C-reactive protein (CRP), inflammatory cytokines and matrix metalloproteinase-2 (MMP-2) activity were assessed at Pre, Post, 24, 48, 72, 96 and 168 h following EIMD. No significant time × group interaction was obtained for muscle strength, vertical jump height recovery and MMP-2 activity (p > 0.05). At 24 h, muscle thickness from the CWI group returned to baseline and was lower than the control (p = 0.04). DOMS returned to baseline at 168 h for the CWI group (p = 0.109) but not for the control (p = 0.008). At 168 h, CK showed a time-group difference with a greater peak for the control group (p = 0.016). In conclusion, multiple CWIs attenuated muscle damage, but not altered systemic inflammation and muscle function recovery.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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