Polyphenols From Grape and Blueberry Improve Episodic Memory in Healthy Elderly with Lower Level of Memory Performance: A Bicentric Double-Blind, Randomized, Placebo-Controlled Clinical Study
Bensalem J, Dudonné S, Etchamendy N, Pellay H, Amadieu C, Gaudout D, Dubreuil S, Paradis ME, Pomerleau S, Capuron L, Hudon C, Layé S, Desjardins Y, Pallet V
The journals of gerontology. Series A, Biological sciences and medical sciences · 80 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Government
- Bpifrance
- Government
- Fonds Unique Interministériel
- Government
- Conseil Régional Aquitaine
- Government
- European Regional Development Fund
Based on 4 listed funder(s).
Publication
- Published
- 2018-07-19 · J Gerontol A Biol Sci Med Sci · vol. 74 · issue 7 · pp. 996–1007
- Publisher
- Oxford University Press
- Cited
- 125 citations · more than 96% of similar papers · 4.8× the field average
- Impact
- Top 10% most cited in its field
- References
- 56 works
- Access
- Paywalled
- Research areas
- Neurological Disease Mechanisms and Treatments · Phytochemicals and Antioxidant Activities · Medicinal Plants and Neuroprotection
- Keywords
- Placebo, Double blind, Episodic memory, Medicine, Randomized controlled trial, Psychology, Cognition, Psychiatry, Internal medicine, Alternative medicine
- MeSH
- humans, vitis, presbycusis, flavonoids, plant extracts, treatment outcome, neuropsychological tests, aging, dietary supplements, aged, middle aged, female, male, polyphenols, memory, episodic, spatial navigation, blueberry plants, recognition, psychology
14 authors
From FR, CA
- Julien BensalemInstitut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement; Complexité, Innovation et Activités Motrices et Sportives; NutriNeuro; Activ'Inside (France)
- Stéphanie DudonnéNutriNeuro; Université Laval
- Nicole EtchamendyInstitut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement; NutriNeuro
- Hermine PellayInstitut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement; Complexité, Innovation et Activités Motrices et Sportives; NutriNeuro; Activ'Inside (France)
- Camille AmadieuInstitut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement; NutriNeuro
- David GaudoutComplexité, Innovation et Activités Motrices et Sportives; Activ'Inside (France)
Abstract
Polyphenols are promising nutritional bioactives exhibiting beneficial effect on age-related cognitive decline. This study evaluated the effect of a polyphenol-rich extract from grape and blueberry (PEGB) on memory of healthy elderly subjects (60-70 years-old). A bicentric, randomized, double-blind, placebo-controlled trial was conducted with 215 volunteers receiving 600 mg/day of PEGB (containing 258 mg flavonoids) or a placebo for 6 months. The primary outcome was the CANTAB Paired Associate Learning (PAL), a visuospatial learning and episodic memory test. Secondary outcomes included verbal episodic and recognition memory (VRM) and working memory (SSP). There was no significant effect of PEGB on the PAL on the whole cohort. Yet, PEGB supplementation improved VRM-free recall. Stratifying the cohort in quartiles based on PAL at baseline revealed a subgroup with advanced cognitive decline (decliners) who responded positively to the PEGB. In this group, PEGB consumption was also associated with a better VRM-delayed recognition. In addition to a lower polyphenol consumption, the urine metabolomic profile of decliners revealed that they excreted more metabolites. Urinary concentrations of specific flavan-3-ols metabolites were associated, at the end of the intervention, with the memory improvements. Our study demonstrates that PEGB improves age-related episodic memory decline in individuals with the highest cognitive impairments.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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