The impact of circulating 25-hydroxyvitamin and oral cholecalciferol treatment on menstrual pain in dysmenorrheic patients
Kucukceran H, Ozdemir O, Kiral S, Berker DS, Kahveci R, Ozkara A, Atalay CR, Ates İ
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 10 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2018-07-25 · Gynecol Endocrinol · vol. 35 · issue 1 · pp. 53–57
- Publisher
- Informa
- Cited
- 15 citations · more than 79% of similar papers · 1.1× the field average
- References
- 12 works
- Access
- Paywalled
- Research areas
- Menstrual Health and Disorders · Endometriosis Research and Treatment · Vitamin D Research Studies
- Keywords
- Medicine, Visual analogue scale, Vitamin D and neurology, Internal medicine, Cholecalciferol, Vitamin, vitamin D deficiency, Gastroenterology, Observational study, Surgery
- MeSH
- humans, vitamin d deficiency, dysmenorrhea, cholecalciferol, vitamin d, pain measurement, treatment outcome, adolescent, female, young adult
8 authors
From TR
- Hatice Küçükceran · correspondingMinistry of Health
- Özhan ÖzdemirAnkara Numune Eğitim ve Araştırma Hastanesi
- Serkan Kiral
- Dilek Sensoz BerkerAnkara Numune Eğitim ve Araştırma Hastanesi
- Rabia KahveciAnkara Numune Eğitim ve Araştırma Hastanesi
- Adem ÖzkaraAnkara Numune Eğitim ve Araştırma Hastanesi
Abstract
This study aims to determine Vitamin-D level in patients with primary dysmenorrhea and investigate the effect of Vitamin-D replacement on symptoms. About 100 patients in the 18-30 age group followed-up with primary dysmenorrhea diagnosis were included in this observational study. The pain severity was assessed using the visual analog scale (VAS). 25-hydroxy vitamin D(25(OH)D) levels of the patients were measured and the replacement therapy was applied according to measurement results. The patients were followed for three months in total. At the end of the three-month period, the 25(OH)D level was measured and the VAS score was assessed once more after the therapy. 25(OH)D level was insufficient in 23.0%, deficient in 45.0%, and severely deficient in 32.0% of the patients. It was found that the VAS score increased as the 25(OH)D level decreased (r = -0.320; p = .002). A significant reduction was observed in VAS scores after Vitamin-D treatment in all three groups; the amount of reduction in VAS score was determined to be higher in the patients with severely deficient levels of 25(OH)D, compared to the patients with deficient or insufficient levels (p < .001). A significant and negative correlation was found between Vitamin-D and symptoms associated with dysmenorrhea in our study. The Vitamin-D replacement therapy led to a significant decrease in symptoms.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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