Effect of a daily snack containing green leafy vegetables on women's fatty acid status: a randomized controlled trial in Mumbai, India
Chopra HV, Kehoe SH, Sahariah SA, Sane HN, Cox VA, Tarwade DV, Margetts BM, Potdar RD, Fall CH, Joshi SR
Asia Pacific journal of clinical nutrition · 3 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food provided by researchers
Who paid for it
- Funding
- Independent funding
- Nonprofit
- Wellcome Trust
- Government
- Department for International Development
- Government
- Medical Research Council
- Grants
- Medical Research Council (U1475000003); Wellcome Trust (098575); Medical Research Council (G0400519); Wellcome Trust (074048)
Based on 3 listed funder(s).
Publication
- Published
- 2019-09-09 · Asia Pac J Clin Nutr · vol. 27 · issue 4 · pp. 804–817
- Publisher
- National Institutes of Health
- Cited
- 5 citations · more than 54% of similar papers · 0.3× the field average
- References
- 0 works
- Access
- Open access (repository copy) · OTHER-OA
- Research areas
- Fatty Acid Research and Health · Antioxidant Activity and Oxidative Stress · Nutritional Studies and Diet
- Keywords
- Malondialdehyde, Polyunsaturated fatty acid, Fatty acid, Medicine, Food science, Glutathione peroxidase, Antioxidant, Superoxide dismutase, Chemistry, Biochemistry
- MeSH
- erythrocytes, humans, vegetables, fatty acids, homocysteine, diet, adolescent, adult, india, female, young adult, snacks
10 authors
From IN, GB
- Harsha ChopraSocial Change and Development
- Sarah Helen KehoeMRC Lifecourse Epidemiology Unit; University of Southampton; Medical Research Council
- Sirazul Ameen SahariahSocial Change and Development
- Harshad SaneSocial Change and Development
- Vanessa CoxMRC Lifecourse Epidemiology Unit; University of Southampton; Medical Research Council
- Dnyaneshwar V TarwadeNarayana Nethralaya
Abstract
Background and objectives
There are few data on the fatty acid status of non-pregnant Indian women. Our objective was to investigate the effect of a snack containing green leafy vegetables (GLVs) on women's erythrocyte long chain polyunsaturated fatty acid status (LCPUFA).
Methods and study design
Non-pregnant women (n=222) aged 14-35 years from Mumbai slums were randomized to consume a snack containing GLVs, fruit and milk (treatment) or a control snack containing foods of low micronutrient content such as potato and onion, daily under observation. One treatment snack contained a mean (SD) of 54.1 (33.7) mg alpha-linolenic acid (ALA) and one control snack contained 4.1 (3.4) mg ALA. Blood was collected at baseline (0 weeks) and after 12 weeks of supplementation. Erythrocyte fatty acids were analyzed using gas chromatography and expressed as g/100g fatty acids. Plasma malondialdehyde, homocysteine, and erythrocyte superoxide dismutase and glutathione peroxidase were measured. The effect of the treatment on 12 week LCPUFA was assessed using ANCOVA models.
Results
Median (IQR) erythrocyte DHA in the treatment group increased from 1.50 (1.11, 2.03) at baseline to 1.86 (1.50, 2.43) (p<0.001) at 12 weeks, and fell in controls from 1.78 (1.37, 2.32) to 1.60 (1.32, 2.04) (p<0.001). The total n-3 fatty acids increased in the treatment group. There was no effect on malondialdehyde and antioxidant enzyme levels. Plasma homocysteine at 0 and 12 weeks was inversely associated with erythrocyte DHA at 12 weeks.
Conclusion
Daily consumption of a snack containing GLV improved women's erythrocyte DHA levels without increasing oxidative stress.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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