Effects of Magnesium Supplementation on Unipolar Depression: A Placebo-Controlled Study and Review of the Importance of Dosing and Magnesium Status in the Therapeutic Response
Ryszewska-Pokraśniewicz B, Mach A, Skalski M, Januszko P, Wawrzyniak ZM, Poleszak E, Nowak G, Pilc A, Radziwoń-Zaleska M
Nutrients · 24 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- University or hospital
- Warszawski Uniwersytet Medyczny
- Government
- Narodowe Centrum Nauki
- University or hospital
- Uniwersytet Warszawski
- Government
- National Science Center [Narodowe Centrum Nauki]
- University or hospital
- Medical University of Warsaw and Institute of Pharmacology PAS, Kraków.
Based on 5 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2018-08-03 · Nutrients · vol. 10 · issue 8 · p. 1014
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 30 citations · more than 84% of similar papers · 1.8× the field average
- References
- 61 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Magnesium in Health and Disease · Bipolar Disorder and Treatment · Coordination Chemistry and Organometallics
- Keywords
- Fluoxetine, Placebo, Magnesium, Antidepressant, Major depressive disorder, Internal medicine, Medicine, Sertraline, Anesthesia, Pharmacology, Chemistry, Serotonin
- MeSH
- humans, fluoxetine, aspartic acid, antidepressive agents, second-generation, treatment outcome, remission induction, double-blind method, affect, depressive disorder, time factors, dietary supplements, adult, aged, middle aged, poland, female, male, young adult, selective serotonin reuptake inhibitors
9 authors
From PL
- Beata Ryszewska-Pokraśniewicz
- Anna Mach · correspondingMedical University of Warsaw
- Michał SkalskiMedical University of Warsaw
- Piotr JanuszkoMedical University of Warsaw
- Zbigniew Maciej WawrzyniakWarsaw University of Technology
- Ewa PoleszakMedical University of Lublin
Abstract
Animal studies using tests and models have demonstrated that magnesium exerts an antidepressant effect. The literature contains few studies in humans involving attempts to augment antidepressant therapy with magnesium ions. The purpose of our study was to assess the efficacy and safety of antidepressant treatment, in combination with magnesium ions. A total of 37 participants with recurrent depressive disorder who developed a depressive episode were included in this study. As part of this double-blind study, treatment with the antidepressant fluoxetine was accompanied with either magnesium ions (120 mg/day as magnesium aspartate) or placebo. During an 8-week treatment period, each patient was monitored for any clinical abnormalities. Moreover, serum fluoxetine and magnesium levels were measured, and pharmaco-electroencephalography was performed. The fluoxetine + magnesium and fluoxetine + placebo groups showed no significant differences in either Hamilton Depression Rating Scale (HDRS) scores or serum magnesium levels at any stage of treatment. Multivariate statistical analysis of the whole investigated group showed that the following parameters increased the odds of effective treatment: lower baseline HDRS scores, female gender, smoking, and treatment augmentation with magnesium. The parameters that increased the odds of remission were lower baseline HDRS scores, shorter history of disease, the presence of antidepressant-induced changes in the pharmaco-EEG profile at 6 h after treatment, and the fact of receiving treatment augmented with magnesium ions. The limitation of this study is a small sample size.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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