Low linolenic and linoleic acid consumption are associated with chronic kidney disease in patients with type 2 diabetes
Dos Santos ALT, Duarte CK, Santos M, Zoldan M, Almeida JC, Gross JL, Azevedo MJ, Lichtenstein AH, Zelmanovitz T
PloS one · 42 citations
How it was studied
- Design
- Cross-sectional study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food diaries or recalls
Who paid for it
- Funding
- Independent funding
- Government
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Nonprofit
- Fundação Instituto de Pesquisas Econômicas
- Unclassified
- FIPE
- Grants
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (502050/2005-5); Fundação Instituto de Pesquisas Econômicas (07-612)
Based on 3 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2018-08-09 · PLoS One · vol. 13 · issue 8 · p. e0195249
- Publisher
- Public Library of Science
- Cited
- 57 citations · more than 92% of similar papers · 3.1× the field average
- Impact
- Top 10% most cited in its field
- References
- 38 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Chronic Kidney Disease and Diabetes · Fatty Acid Research and Health · Nutritional Studies and Diet
- Keywords
- Medicine, Type 2 diabetes, Diabetes mellitus, Kidney disease, Internal medicine, Renal function, Body mass index, Gastroenterology, Albuminuria, Endocrinology, Blood pressure
- MeSH
- humans, diabetic nephropathies, diabetes mellitus, type 2, dietary fats, alpha-linolenic acid, linoleic acid, diet surveys, risk factors, cross-sectional studies, feeding behavior, aged, middle aged, brazil, female, male, renal insufficiency, chronic
9 authors
From BR, US
- Ana Luiza Teixeira dos SantosUniversidade Federal do Rio Grande do Sul
- Camila Kümmel DuarteUniversidade Federal do Rio Grande do Sul
- Manoella Freitas SantosUniversidade Federal do Rio Grande do Sul; Hospital de Clínicas de Porto Alegre
- Maira ZoldanUniversidade Federal do Rio Grande do Sul; Hospital de Clínicas de Porto Alegre
- Jussara Carnevalle AlmeidaUniversidade Federal do Rio Grande do Sul
- Jorge Luiz GrossUniversidade Federal do Rio Grande do Sul; Hospital de Clínicas de Porto Alegre
Abstract
Aim
This cross-sectional study aimed to assess the association of the fat content in the diet with Diabetic Kidney Disease (DKD) in patients with type 2 diabetes.
Methodology
Patients from the Diabetes research clinic at Hospital de Clínicas de Porto Alegre (Brazil) were consecutively recruited. The inclusion criterion was the diagnosis of type 2 diabetes. The exclusion criteria were as follows: body mass index >40 kg/m2, heart failure, gastroparesis, diabetic diarrhea, dietary counseling by a registered dietitian during the previous 12 months, and inability to perform the weighed diet records (WDR). The dietary fatty acids (saturated, monounsaturated and polyunsaturated) consumption was estimated by 3-day WDR. Compliance with the WDR technique was assessed by comparison of protein intake estimated from the 3-day WDR and from the 24-h urinary nitrogen output performed on the third day of the WDR period. The presence of DKD was defined as urinary albumin excretion (UAE) ≥ 30 mg / 24 h or/and glomerular filtration rate (eGFR) <60 ml/min/1.73 m2. Urinary albumin was measured twice and eGFR was estimated by using the CKD-EPI equation.
Results
A total of 366 patients were evaluated; of these, 33% (n = 121) had DKD. Multivariate analysis showed that the intake of linolenic acid was negatively associated with DKD (OR = 0.57; 95% CI 0.35-0.93; P = 0.024), adjusted for gender, smoking, cardiovascular disease, ACE inhibitors and/or angiotensin receptor blocker use, systolic blood pressure, fasting plasma glucose and HDL cholesterol. In a separate model, similar results were observed for linoleic acid, adjusting to the same co-variables (OR = 0.95; 95% CI 0.91-0.99; P = 0.006).
Conclusion
The lower intake of polyunsaturated fatty acids, especially linolenic and linoleic acid, is associated with chronic kidney disease in patients with type 2 diabetes.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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