Hypomagnesemia in diabetes patients: comparison of serum and intracellular measurement of responses to magnesium supplementation and its role in inflammation
Zghoul N, Alam-Eldin N, Mak IT, Silver B, Weglicki WB
Diabetes, metabolic syndrome and obesity : targets and therapy · 17 citations
How it was studied
- Design
- Controlled clinical trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Nonprofit
- Kuwait Foundation for the Advancement of Sciences
Based on 1 listed funder(s).
Publication
- Published
- 2018-08-01 · Diabetes Metab Syndr Obes · vol. Volume 11 · pp. 389–400
- Publisher
- Dove Medical Press
- Cited
- 25 citations · more than 81% of similar papers · 1.6× the field average
- References
- 42 works
- Access
- Open access (journal) · CC-BY-NC
- Research areas
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Potassium and Related Disorders
- Keywords
- Hypomagnesemia, Magnesium, Inflammation, Diabetes mellitus, Medicine, Magnesium deficiency (plants), Internal medicine, Intracellular, Gastroenterology, Endocrinology, Chemistry, Biochemistry
5 authors
From KW, US
- Nadia ZghoulDasman Diabetes Institute
- Nada Alam-EldinDasman Diabetes Institute
- Ivan Tong MakGeorge Washington University
- Burton B. Silver
- William B. WeglickiGeorge Washington University
Abstract
Purpose
In this clinical trial, we assessed the efficacy of magnesium (Mg) supplementation in hypomagnesemic type 2 diabetes patients in restoring serum and intracellular Mg levels. The study had two coprimary end points: the change in serum and intracellular Mg level between baseline and after 3 months of supplementation. We compared the efficacy with regard to lowering hemoglobin A1c (HbA1c), C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), and 8-isoprostane as secondary end points.
Patients and methods
In an open-label trial, 47 hypomagnesemic type 2 diabetes patients were administered 336 mg Mg daily. At baseline and after 3 months, serum, cellular Mg, and inflammation biomarkers were measured. For intracellular Mg levels, sublingual epithelial cells were analyzed by analytical scanning electron microscopy using computerized elemental X-ray analysis. Blood samples were analyzed for Mg, creatinine, HbA1c, and CRP. Systemic inflammatory markers including TNF-α and the oxidative stress marker 8-isoprostane were determined using enzyme-linked immunosorbent assay.
Results
Mg supplementation significantly increased the intracellular and serum levels. Statistically clinical improvement in HbA1c and CRP levels was not observed, but significant decreases in TNF-α as well as in 8-isoprostane were found.
Conclusion
A feasible clinical method for the assessment of intracellular Mg was demonstrated in tissue samples obtained noninvasively, providing evidence for potential clinical translation of this method to routinely determine intracellular Mg concentration.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC).
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