Randomized Trial of a High Protein, Partial Meal Replacement Program with or without Alternate Day Fasting: Similar Effects on Weight Loss, Retention Status, Nutritional, Metabolic, and Behavioral Outcomes
Bowen J, Brindal E, James-Martin G, Noakes M
Nutrients · 62 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- Commonwealth Scientific and Industrial Research Organisation
- Government
- CSIRO Strategic; CSIRO Royality Funds from ImpromyTM
Based on 2 listed funder(s).
Publication
- Published
- 2018-08-23 · Nutrients · vol. 10 · issue 9 · p. 1145
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 83 citations · more than 94% of similar papers · 3.5× the field average
- Impact
- Top 10% most cited in its field
- References
- 45 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Dietary Effects on Health · Diet and metabolism studies · Obesity and Health Practices
- Keywords
- Weight loss, Randomized controlled trial, Meal, Medicine, Intermittent fasting, Gerontology, Obesity, Internal medicine
- MeSH
- humans, weight loss, zinc, vitamin b 12, folic acid, insulin, blood glucose, triglycerides, thiamine, vitamin d, c-reactive protein, transferrin, dietary proteins, body mass index, caloric restriction, fasting, nutritional status, blood pressure, adult, middle aged, female, male, cholesterol, ldl, ferritins, meals, biomarkers, diet, high-protein
4 authors
From AU
- Jane Bowen · correspondingCSIRO Health and Biosecurity
- Emily BrindalCSIRO Health and Biosecurity
- Genevieve James‐MartinCSIRO Health and Biosecurity
- Manny NoakesCSIRO Health and Biosecurity
Abstract
Higher-protein diets, meal replacements, and greater early weight loss have separately been associated with greater weight loss. We compared a high-protein, meal replacement program with daily energy restriction (DER) to one which provided greater energy restriction adding alternate day fasting (ADF + DER; alternating days of modified-fasting and DER plus 1 ad libitum day/week) on retention, weight loss, physiological, nutritional, and behavioral markers. Participants were randomized to ADF + DER or DER for 16 weeks (n = 162, age 40 ± 8 years BMI 36 ± 6 kg/m² (Mean ± SD)) plus 8 weeks weight maintenance. At week 16 weight change was -10.7 ± 0.5 kg and -11.2 ± 0.6 kg in ADF + DER and DER groups (treatment NS). Fat mass, visceral adipose tissue, and lean mass (p p p p < 0.05). This study supports the use of higher protein, meal replacement programs with or without ADF in weight management.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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