Funded in part by Discovery Foundation, Thermo-Fisher South Africa, Nestlé Nutrition Institute Africa
Predictive values of alpha-gal IgE levels and alpha-gal IgE: Total IgE ratio and oral food challenge-proven meat allergy in a population with a high prevalence of reported red meat allergy
Mabelane T, Basera W, Botha M, Thomas HF, Ramjith J, Levin ME
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 99 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cross-sectional study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Industry funded
- Nonprofit
- Discovery Eye Foundation
- University or hospital
- Department of Paediatrics, University of Melbourne
- Nonprofit
- Allergy Society of South Africa
- Company
- Discovery Foundation
- Company
- Thermo-Fisher South Africa
- University or hospital
- Department of Paediatrics
- Company
- Nestlé Nutrition Institute Africa
Based on 7 listed funder(s).
Publication
- Published
- 2018-08-24 · Pediatr Allergy Immunol · vol. 29 · issue 8 · pp. 841–849
- Publisher
- Wiley
- Cited
- 129 citations · more than 98% of similar papers · 6.6× the field average
- Impact
- Top 10% most cited in its field
- References
- 31 works
- Access
- Paywalled
- Research areas
- Food Allergy and Anaphylaxis Research · Allergic Rhinitis and Sensitization · Contact Dermatitis and Allergies
- Keywords
- Medicine, Immunoglobulin E, Allergy, Food allergy, Sensitization, Oral food challenge, Population, Immunology, Red meat, Anaphylaxis, Antibody, Pathology, Environmental health
- MeSH
- humans, food hypersensitivity, disaccharides, immunoglobulin e, allergens, immunologic tests, prevalence, sensitivity and specificity, cross-sectional studies, phenotype, meat, adolescent, adult, aged, middle aged, child, female, male, young adult, surveys and questionnaires
6 authors
From ZA, NL, GB
- Tshegofatso MabelaneUniversity of Cape Town
- Wisdom BaseraWestern Cape Department of Health; University of Cape Town
- Maresa BothaUniversity of Cape Town
- Heidi Facey ThomasUniversity of Cape Town
- Jordache RamjithRadboud University Nijmegen; University of Cape Town; Radboud University Medical Center; Radboud Institute for Molecular Life Sciences
- Michael Eliad Levin · correspondingUniversity of Cape Town; Worldwide Universities Network
Abstract
Background
Severe meat allergy with anaphylaxis may be caused by sensitization to alpha-gal. Levels of alpha-gal sensitization that correlate with high risk of meat allergy are currently unknown. We have identified an area with a high prevalence of reported red meat allergy which offered the opportunity to evaluate the diagnostic value of IgE antibody tests.
Methods
To determine levels of alpha-gal IgE and alpha-gal:total IgE ratio in a large cohort of subjects with challenge-proven meat allergy compared with control subjects from the same environment, we conducted fieldwork assessing 131 participants who reported adverse reactions to meat, and 26 control subjects, by questionnaires, IgE sensitization to alpha-gal and oral food challenge to beef sausage.
Results
Eighty-four participants were diagnosed with alpha-gal allergy. Alpha-gal IgE ranged between 0.7 and 344.5 kU/L. Alpha-gal:total IgE ratio ranged from 0.1% to 67.6%. Logistic regression analysis showed both alpha-gal IgE and alpha-gal:total IgE ratio strongly correlated with meat allergy, with AUC of 0.95. The values giving the best correct classification were IgE of 2.00 kU/L and ratio of 0.75%. The value above which there is a 95% probability of meat allergy is IgE>5.5 kU/L and ratio of 2.12%.
Conclusion
Alpha-gal allergy in a population with a high prevalence of reported red meat allergy showed a more rapid onset of symptoms than previously described and a high prevalence of isolated subjective gastrointestinal manifestations. Cutoff values are described for levels of sensitization to alpha-gal IgE and alpha-gal:total IgE ratio that are highly likely to result in clinically significant meat allergy.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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