Low 25-hydroxyvitamin D levels and the risk of frailty syndrome: a systematic review and dose-response meta-analysis
Ju SY, Lee JY, Kim DH
BMC geriatrics · 57 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- University or hospital
- Catholic University of Korea
- University or hospital
- College of Medicine, Catholic University of Korea
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2018-09-04 · BMC Geriatr · vol. 18 · issue 1 · p. 206
- Publisher
- BioMed Central
- Cited
- 84 citations · more than 85% of similar papers · 2.0× the field average
- References
- 51 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Vitamin D Research Studies · Gut microbiota and health · HIV-related health complications and treatments
- Keywords
- Medicine, Meta-analysis, Vitamin D and neurology, Akaike information criterion, Internal medicine, vitamin D deficiency, Confidence interval, Cohort study, Prospective cohort study, Cochrane Library, Relative risk, Frailty syndrome, Cohort, Statistics
- MeSH
- humans, vitamin d, geriatric assessment, incidence, aged, frail elderly, global health, frailty
3 authors
From KR
- Sang-Yhun Ju · correspondingThe Catholic University of Korea Yeouido St. Mary's Hospital; Catholic University of Korea
- Juneyoung LeeKorea University
- Do‐Hoon KimKorea University; Ansan University; Korea University Ansan Hospital
Abstract
Background
Vitamin D deficiency and frailty are common with aging. Previous studies examining vitamin D status and frailty have produced mixed results, and in particular, the shape of the association has not been well established. We examined the association between 25-hydroxyvitamin D (25OHD) serum levels and frailty by performing a systematic review and dose-response meta-analysis.
Methods
We searched the PubMed, EMBASE and Cochrane Library databases of Elsevier through February 2017. Cross-sectional and cohort studies that reported adjusted risk ratios with 95% confidence intervals (CI) for frailty with ≥3 categories of 25OHD serum levels were selected. Data extraction was performed independently by two authors. The reported risk estimates for 25OHD categories were recalculated, employing a comprehensive trend estimation from summarized dose-response data.
Results
The pooled risk estimate of frailty syndrome per 25 nmol/L increment in serum 25OHD concentration was 0.88 (95% CI = 0.82-0.95, I2 = 86.8%) in the 6 cross-sectional studies and 0.89 (95% CI = 0.85-0.94, I2 = 0.0%) in the 4 prospective cohort studies. Based on the Akaike information criteria (AIC), a linear model was selected (AIC for the nonlinear model: - 5.4, AIC for the linear model: - 6.8 in the prospective cohort studies; AIC for the linear model: - 13.6, AIC for the nonlinear model: - 1.77 in the cross-sectional studies).
Conclusions
This dose-response meta-analysis indicates that serum 25OHD levels are significantly and directly associated with the risk of frailty. Further studies should address the underlying mechanisms to explain this relationship and to determine whether vitamin D supplementation is effective for preventing frailty syndrome.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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