Funded in part by H. Lundbeck A/S
Effect of fish oil supplementation in pregnancy on bone, lean, and fat mass at six years: randomised clinical trial
Vinding RK, Stokholm J, Sevelsted A, Sejersen T, Chawes BL, Bønnelykke K, Thorsen J, Howe LD, Krakauer M, Bisgaard H
BMJ (Clinical research ed.) · 34 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Industry funded
- Government
- Strategiske Forskningsråd
- University or hospital
- University of Bristol
- Nonprofit
- Lundbeckfonden
- Company
- H. Lundbeck A/S
- Government
- Medical Research Council
- Grants
- Strategiske Forskningsråd (0603–00280B); Medical Research Council (MC_UU_12013_5); Lundbeckfonden (R16‐A1694); Medical Research Council (MC_UU_12013); Medical Research Council (MR/M020894); Medical Research Council (MR/M020894/1); University of Bristol (MC_UU_12013/5); Medical Research Council (MR/M020894/1)
Based on 5 listed funder(s).
Publication
- Published
- 2018-09-04 · BMJ · vol. 362 · p. k3312
- Cited
- 57 citations · more than 97% of similar papers · 5.4× the field average
- Impact
- Top 10% most cited in its field
- References
- 37 works
- Access
- Open access (hybrid journal) · CC-BY-NC
- Research areas
- Fatty Acid Research and Health · Birth, Development, and Health · Gestational Diabetes Research and Management
- Keywords
- Fish oil, Pregnancy, Medicine, Lean body mass, Fish <Actinopterygii>, Clinical trial, Fish bone, Randomized controlled trial, Obstetrics, Internal medicine, Biology, Body weight, Fishery
- MeSH
- humans, prenatal exposure delayed effects, fatty acids, omega-3, fish oils, absorptiometry, photon, body mass index, prenatal care, prospective studies, double-blind method, bone development, pregnancy, bone density, dietary supplements, adult, child, infant, female, infant nutritional physiological phenomena, maternal nutritional physiological phenomena
10 authors
From DK, GB
- Rebecca VindingUniversity of Copenhagen; Gentofte Hospital; Næstved Sygehus; Copenhagen Prospective Studies on Asthma in Childhood
- Jakob StokholmUniversity of Copenhagen; Gentofte Hospital; Copenhagen Prospective Studies on Asthma in Childhood
- Astrid SevelstedUniversity of Copenhagen; Gentofte Hospital; Copenhagen Prospective Studies on Asthma in Childhood
- Tobias Steen SejersenUniversity of Copenhagen; Gentofte Hospital; Næstved Sygehus; Copenhagen Prospective Studies on Asthma in Childhood
- Bo ChawesUniversity of Copenhagen; Gentofte Hospital; Copenhagen Prospective Studies on Asthma in Childhood
- Klaus BønnelykkeUniversity of Copenhagen; Gentofte Hospital; Copenhagen Prospective Studies on Asthma in Childhood
Abstract
Objective
To examine the effect of supplementation with n-3 long chain polyunsaturated fatty acids (n-3 LCPUFA) in pregnancy on anthropometry and body composition in offspring.
Design
Double blinded, randomised controlled trial.
Setting
Copenhagen Prospective Studies on Asthma in Childhood2010 cohort.
Participants
736 pregnant women and their offspring.
Intervention
n-3 LCPUFA (fish oil) or control (olive oil) daily from pregnancy week 24 until one week after birth.
Main outcome measures
Height/length, weight, head, and waist measurements and body composition from dual energy x ray absorptiometry (all pre-specified secondary endpoints of the n-3 LCPUFA trial; the primary outcome for the trial was persistent wheeze/asthma).
Results
The mean body mass index (BMI) z score was increased between age 0 and 6 years in the fish oil supplementation group compared with the control group (0.14 (95% confidence interval 0.04 to 0.23); P=0.006). At 6 years, supplementation was associated with a higher BMI z score (0.19 (0.06 to 0.32); P=0.004), a higher weight/height (3.48 (0.38 to 6.57) g/cm; P=0.03), and a larger waist circumference (0.6 (0.0 to 1.2) cm; P=0.04) but not a higher proportion of obese children, using International Obesity Task Force grades. The dual energy x ray absorptiometry scan at age 6 years showed a higher total mass (395.4 (86.6 to 704.3) g; P=0.01) in the supplementation versus the control group, explained by a higher lean mass (280.7 (98.9 to 462.4) g; P=0.002), a higher bone mineral content (10.3 (2.3 to 18.1) g; P=0.01), and a non-significantly higher fat mass (116.3 (-92.9 to 325.5) g; P=0.28), but no differences were seen in total body fat or lean mass percentage.
Conclusion
Fish oil supplementation from the 24th week of pregnancy led to a higher BMI in the offspring from 0 to 6 years of age but not an increased risk of obesity at age 6. The body composition at age 6 years in children given fish oil supplementation was characterised by a proportional increase in lean, bone, and fat mass suggesting a general growth stimulating effect of n-3 LCPUFA.
Trial registration
Clinicaltrials.gov NCT00798226.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC).
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