Consumption of red and processed meat and breast cancer incidence: A systematic review and meta-analysis of prospective studies
Farvid MS, Stern MC, Norat T, Sasazuki S, Vineis P, Weijenberg MP, Wolk A, Wu K, Stewart BW, Cho E
International journal of cancer · 94 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Government
- National Cancer Institute
- Government
- NCI NIH HHS
- Grants
- National Cancer Institute (P30 CA014089)
Based on 2 listed funder(s).
Publication
- Published
- 2018-09-05 · Int J Cancer · vol. 143 · issue 11 · pp. 2787–2799
- Publisher
- Wiley
- Cited
- 140 citations · more than 91% of similar papers · 2.7× the field average
- Impact
- Top 10% most cited in its field
- References
- 45 works
- Access
- Free to read
- Research areas
- Nutritional Studies and Diet · Nutrition, Genetics, and Disease · Phytoestrogen effects and research
- Keywords
- Medicine, Breast cancer, Prospective cohort study, Odds ratio, Red meat, Relative risk, Incidence (geometry), Meta-analysis, Cohort study, Confidence interval, Internal medicine, Cancer, Pathology
- MeSH
- humans, breast neoplasms, incidence, risk factors, epidemiologic studies, case-control studies, prospective studies, meat products, databases, factual, adult, aged, middle aged, female, young adult, observational studies as topic, red meat
10 authors
From US, GB, IT, NL, SE, AU
- Maryam Sadat Farvid · correspondingHarvard University
- Mariana Carla SternUniversity of Southern California; USC Norris Comprehensive Cancer Center
- Teresa NoratImperial College London
- Shizuka SasazukiPrevention Group
- Paolo VineisPublic Health England; Italian institute for Genomic Medicine; Imperial College London
- Matty P. WeijenbergMaastricht University; Maastro Clinic
Abstract
Prior studies on red and processed meat consumption with breast cancer risk have generated inconsistent results. We performed a systematic review and meta-analysis of prospective studies to summarize the evidence regarding the relation of red meat and processed meat consumption with breast cancer incidence. We searched in MEDLINE and EMBASE databases through January 2018 for prospective studies that reported the association between red meat and processed meat consumption with incident breast cancer. The multivariable-adjusted relative risk (RR) was combined comparing the highest with the lowest category of red meat (unprocessed) and processed meat consumption using a random-effect meta-analysis. We identified 13 cohort, 3 nested case-control and two clinical trial studies. Comparing the highest to the lowest category, red meat (unprocessed) consumption was associated with a 6% higher breast cancer risk (pooled RR,1.06; 95% confidence intervals (95%CI):0.99-1.14; I2 = 56.3%), and processed meat consumption was associated with a 9% higher breast cancer risk (pooled RR, 1.09; 95%CI, 1.03-1.16; I2 = 44.4%). In addition, we identified two nested case-control studies evaluating the association between red meat and breast cancer stratified by N-acetyltransferase 2 acetylator genotype. We did not observe any association among those with either fast (per 25 g/day pooled odds ratio (OR), 1.18; 95%CI, 0.93-1.50) or slow N-acetyltransferase 2 acetylators (per 25 g/day pooled OR, 0.99; 95%CI, 0.91-1.08). In the prospective observational studies, high processed meat consumption was associated with increased breast cancer risk.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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