Dietary nitrate improved exercise capacity in COPD but not blood pressure or pulmonary function: a 2 week, double-blind randomised, placebo-controlled crossover trial
Kerley CP, James PE, McGowan A, Faul J, Cormican L
International journal of food sciences and nutrition · 21 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2018-09-06 · Int J Food Sci Nutr · vol. 70 · issue 2 · pp. 222–231
- Publisher
- Taylor & Francis
- Cited
- 29 citations · more than 93% of similar papers · 4.3× the field average
- Impact
- Top 10% most cited in its field
- References
- 36 works
- Access
- Paywalled
- Research areas
- Cardiovascular and exercise physiology · Chronic Obstructive Pulmonary Disease (COPD) Research · Nitric Oxide and Endothelin Effects
- Keywords
- Medicine, Crossover study, COPD, Dietary Nitrate, Placebo, Blood pressure, Nitric oxide, Nitrate, Ambulatory blood pressure, Exhaled nitric oxide, Pulmonary function testing, Nitrite, Internal medicine, Cardiology, Lung function, Pathology, Lung
- MeSH
- lung, humans, beta vulgaris, pulmonary disease, chronic obstructive, nitrates, nitrites, nitric oxide, blood pressure monitoring, ambulatory, exercise, walking, cross-over studies, double-blind method, blood pressure, exercise tolerance, quality of life, dietary supplements, aged, middle aged, female, male, fruit and vegetable juices
5 authors
From IE, GB
- Conor P. Kerley · correspondingConnolly Hospital Blanchardstown
- Philip E. JamesCardiff Metropolitan University
- Aisling McGowanConnolly Hospital Blanchardstown
- John L. FaulConnolly Hospital Blanchardstown
- Liam J. CormicanConnolly Hospital Blanchardstown
Abstract
Dietary nitrate may improve exercise tolerance in some healthy and clinical populations. Existing data regarding dietary nitrate in COPD is inconsistent. We conducted a 14d double-blind, randomised, placebo-controlled, crossover trial of daily nitrate-rich beetroot juice (BRJ; 12.9 mmol) versus nitrate-depleted BRJ (PL; 0.5 mmol). At baseline and after each condition, we assessed functional capacity (incremental shuttle walk test; ISWT), ambulatory blood pressure, pulmonary function, quality of life as well as exhaled nitric oxide (eNO), and plasma nitrate/nitrite (NOx). Eight subjects with COPD completed the trial. BRJ supplementation was associated with significantly increased NOx (p < .05) and a 14.6% increase in ISWT distance (+56 m, p = .00004) as well as a trend towards increased eNO compared to PL. There was no other differences. Dietary nitrate appears to have ergogenic effect in subjects with mild-moderate COPD. This effect does not appear to be related to altering blood pressure or pulmonary function.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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