Sex difference in cold perception and shivering onset upon gradual cold exposure
Kaikaew K, van den Beukel JC, Neggers SJCMM, Themmen APN, Visser JA, Grefhorst A
Journal of thermal biology · 44 citations
How it was studied
- Design
- Controlled clinical trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- University or hospital
- Chulalongkorn University
- University or hospital
- Faculty of Medicine, Chulalongkorn University
- University or hospital
- Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands
- University or hospital
- Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
Based on 4 listed funder(s).
Publication
- Published
- 2018-08-23 · J Therm Biol · vol. 77 · pp. 137–144
- Publisher
- Elsevier BV
- Cited
- 75 citations · more than 95% of similar papers · 4.0× the field average
- Impact
- Top 10% most cited in its field
- References
- 42 works
- Access
- Open access (hybrid journal) · CC-BY-NC-ND
- Research areas
- Adipose Tissue and Metabolism · Thermoregulation and physiological responses · Exercise and Physiological Responses
- Keywords
- Shivering, Thermoregulation, Medicine, Significant difference, Anesthesia, Internal medicine
- MeSH
- humans, body temperature, body temperature regulation, shivering, skin temperature, sex characteristics, adolescent, adult, female, male, cold temperature, young adult, thermosensing
6 authors
From TH, NL
- Kasiphak KaikaewChulalongkorn University; Erasmus MC
- Johanna C. van den BeukelErasmus MC
- Sebastian J.C.M.M. NeggersErasmus MC
- Axel P. N. ThemmenErasmus MC
- Jenny A. Visser · correspondingErasmus MC; Erasmus University Rotterdam
- Aldo GrefhorstErasmus MC
Abstract
To maintain a thermal balance when experiencing cold, humans reduce heat loss and enhance heat production. A potent and rapid mechanism for heat generation is shivering. Research has shown that women prefer a warmer environment and feel less comfortable than men in the same thermal condition. Using the Blanketrol® III, a temperature management device commonly used to study brown adipose tissue activity, we tested whether the experimental temperature (TE) at which men and women start to shiver differs. Twenty male and 23 female volunteers underwent a cooling protocol, starting at 24 °C and gradually decreasing by 1-2 °C every 5 min until an electromyogram detected the shivering or the temperature reached 9 °C. Women started shivering at a higher TE than men (11.3 ± 1.8 °C for women vs 9.6 ± 1.8 °C for men, P = 0.003). In addition, women felt cool, scored by a visual analogue scale, at a higher TE than men (18.3 ± 3.0 °C for women vs 14.6 ± 2.6 °C for men, P < 0.001). This study demonstrates a sex difference in response to cold exposure: women require shivering as a source of heat production earlier than men. This difference could be important and sex should be considered when using cooling protocols in physiological studies.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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