Serum Parathyroid Hormone, 25-Hydroxyvitamin D, and Risk of Alzheimer's Disease: A Mendelian Randomization Study
Larsson SC, Traylor M, Markus HS, Michaëlsson K
Nutrients · 32 citations
How it was studied
- Design
- Case-control study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- Government
- National Institute for Health and Care Research
- Nonprofit
- Hjärnfonden
- Government
- National Institute for Health Research (NIHR)
- Grants
- National Institute for Health and Care Research (NF-SI-0512-10019); National Institute for Health and Care Research (NF-SI-0617-10006); Hjärnfonden (F02017-0163)
Based on 3 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2018-09-06 · Nutrients · vol. 10 · issue 9 · p. 1243
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 43 citations · more than 94% of similar papers · 3.7× the field average
- Impact
- Top 10% most cited in its field
- References
- 36 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Vitamin D Research Studies · Bone health and osteoporosis research · Parathyroid Disorders and Treatments
- Keywords
- Mendelian randomization, Parathyroid hormone, Vitamin D and neurology, Internal medicine, Odds ratio, Endocrinology, Alzheimer's disease, Medicine, Single-nucleotide polymorphism, Hormone, Disease, Biology, Genetics, Genotype, Gene, Calcium, Genetic variants
- MeSH
- humans, alzheimer disease, genetic predisposition to disease, parathyroid hormone, vitamin d, risk factors, case-control studies, gene frequency, phenotype, polymorphism, single nucleotide, genome-wide association study, mendelian randomization analysis, protective factors, biomarkers
4 authors
From SE, GB
- Susanna C. Larsson · correspondingKarolinska Institutet
- Matthew TraylorUniversity of Cambridge
- Hugh Stephen MarkusUniversity of Cambridge
- Karl MichaëlssonUppsala University
Abstract
We conducted Mendelian randomization analyses to investigate the associations of serum parathyroid hormone (S-PTH) and serum 25-hydroxyvitamin D (S-25OHD) concentrations with Alzheimer's disease (AD). Five and seven single nucleotide polymorphisms associated with S-PTH and S-25OHD concentrations, respectively, were used as instrumental variables. Data for AD were acquired from the International Genomics of Alzheimer's Project (17,008 AD cases and 37,154 controls). Genetically higher S-PTH concentrations were not associated with AD (odds ratio per standard deviation increase in S-PTH = 1.11; 95% CI 0.97⁻1.26; p = 0.12). In contrast, all seven 25OHD-increasing alleles were inversely associated with AD and two of the associations were statistically significant (p p = 0.002). This study provides evidence that vitamin D may play a role in AD but found no significant association between S-PTH and AD.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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