Treatment of Darier's disease with oral magnesium: a case report
Oi-Yee Li H, Colantonio S, Kanigsberg N
SAGE open medical case reports · 4 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Case report (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2018-01-01 · SAGE Open Med Case Rep · vol. 6 · p. 2050313X18795071
- Publisher
- SAGE Publishing
- Cited
- 14 citations · more than 76% of similar papers · 0.8× the field average
- References
- 5 works
- Access
- Open access (journal) · CC-BY-NC
- Research areas
- Genetic and rare skin diseases. · Hedgehog Signaling Pathway Studies · Ocular Disorders and Treatments
- Keywords
- Medicine, Darier's disease, Darier Disease, Magnesium, Endoplasmic reticulum, Dermatology, Genodermatosis, Disease, Internal medicine, Gene, Biology, Genetics
3 authors
From CA
- Heidi Oi‐Yee LiUniversity of Ottawa
- Sophia ColantonioUniversity of Ottawa
- Nordau D. Kanigsberg · correspondingOttawa Hospital
Abstract
Darier's disease, an autosomal dominant genodermatosis, arises from a mutation in the ATP2A2 gene that codes for sarco/endoplasmic reticulum Ca2+-ATPase in the endoplasmic reticulum and is characterized by greasy keratotic papules commonly found in seborrheic regions. Conventional treatments, including topical corticosteroids, antibiotics, antifungals and retinoids, often have limited efficacy. The present article reports the novel use of oral magnesium chloride supplementation (300 mg daily) in the treatment of Darier disease. After 5 years of limited improvement using conventional therapies, significant improvements in neck lesions were observed within 1 month of starting oral magnesium chloride. This suggests that oral magnesium chloride may be an effective therapeutic option for Darier disease, although further in vitro and clinical trials are necessary to evaluate its clinical efficacy.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC).
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.