Impact of Genetic Variability on Physiological Responses to Caffeine in Humans: A Systematic Review
Fulton JL, Dinas PC, Carrillo AE, Edsall JR, Ryan EJ, Ryan EJ
Nutrients · 50 citations
How it was studied
- Design
- Systematic review (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2018-09-25 · Nutrients · vol. 10 · issue 10 · p. 1373
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 69 citations · more than 72% of similar papers · 1.1× the field average
- References
- 47 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Coffee research and impacts · Eating Disorders and Behaviors
- Keywords
- Caffeine, Single-nucleotide polymorphism, Medicine, rs4680, CYP1A2, Pharmacology, Biology, Physiology, Genetics, Genotype, Psychiatry, Internal medicine, Gene, Cytochrome P450
- MeSH
- humans, caffeine, cytochrome p-450 cyp1a2, receptor, adenosine a2a, receptors, aryl hydrocarbon, anxiety, genotype, polymorphism, single nucleotide, adult, middle aged, female, male, performance-enhancing substances, pharmacogenomic variants, basic helix-loop-helix proteins
6 authors
From US, GR
- Jacob L. FultonChatham University
- Petros C. DinasUniversity of Thessaly
- Andres E. CarrilloUniversity of Thessaly; Chatham University
- Jason R. EdsallChatham University
- Emily J. RyanWest Virginia University; Chatham University
- Edward J. Ryan · correspondingWest Virginia University; Chatham University
Abstract
Emerging research has demonstrated that genetic variation may impact physiological responses to caffeine consumption. The purpose of the present review was to systematically recognize how select single nucleotide polymorphisms (SNPs) impact habitual use of caffeine as well as the ergogenic and anxiogenic consequences of caffeine. Two databases (PubMed and EBSCO) were independently searched using the same algorithm. Selected studies involved human participants and met at least one of the following inclusion criteria: (a) genetic analysis of individuals who habitually consume caffeine; (b) genetic analysis of individuals who underwent measurements of physical performance with the consumption of caffeine; (c) genetic analysis of individuals who underwent measurements of mood with the consumption of caffeine. We included 26 studies (10 randomized controlled trials, five controlled trials, seven cross-sectional studies, three single-group interventional studies and one case-control study). Single nucleotide polymorphisms in or near the cytochrome P450 (CYP1A2) and aryl hydrocarbon receptor (AHR) genes were consistently associated with caffeine consumption. Several studies demonstrated that the anxiogenic consequences of caffeine differed across adenosine 2a receptor (ADORA2A) genotypes, and the studies that investigated the effects of genetic variation on the ergogenic benefit of caffeine reported equivocal findings (CYP1A2) or warrant replication (ADORA2A).
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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