Effects of Laser Photobiomodulation and Ozone Therapy on Palatal Epithelial Wound Healing and Patient Morbidity
Isler SC, Uraz A, Guler B, Ozdemir Y, Cula S, Cetiner D
Photomedicine and laser surgery · 41 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- National Institutes of Health
Based on 1 listed funder(s).
Publication
- Published
- 2018-09-27 · Photomed Laser Surg · vol. 36 · issue 11 · pp. 571–580
- Publisher
- Mary Ann Liebert, Inc.
- Cited
- 73 citations · more than 93% of similar papers · 3.2× the field average
- Impact
- Top 10% most cited in its field
- References
- 43 works
- Access
- Paywalled
- Research areas
- Laser Applications in Dentistry and Medicine · Medical and Biological Ozone Research · Dental Implant Techniques and Outcomes
- Keywords
- Medicine, Visual analogue scale, Digital image analysis, Low level laser therapy, Ozone therapy, Laser therapy, Dentistry, Wound healing, Surgery, Clinical efficacy, Laser, Pathology
- MeSH
- mouth mucosa, palate, humans, gingival recession, hydrogen peroxide, ozone, pain measurement, treatment outcome, combined modality therapy, prospective studies, wound healing, adult, turkey, female, male, transplant donor site, re-epithelialization, low-level light therapy
6 authors
From TR
- Sıla Çağrı İşlerGazi University
- Ahu UrazGazi University
- Berceste GülerKütahya Dumlupınar Üniversitesi
- Yücel ÖzdemirGazi University
- Serpil CulaBaşkent University
- Deniz Çetiner · correspondingGazi University
Abstract
Objective
The aim of this study was to compare the effects of laser photobiomodulation (PBM) and topical ozone therapy on the reepithelialization of palatal donor site wounds through clinical assessment and computer-aided image analysis and to assess the patient morbidity following free gingival graft (FGG) surgeries.
Material and methods
Thirty-six patients requiring FGG were randomly allocated into three groups: laser group (n = 12), ozone group (n = 12), and control group (n = 12). Epithelialization was evaluated by applying 3% hydrogen peroxide (H2O2) to the wound area and also measured by using digital image analysis (ImageJ). Bland-Altman plots were used for assessing agreement between H2O2 and ImageJ measurements. Parameters in relation to patient morbidity were assessed by using visual analog scale (VAS) on the first 3, 7, 14, and 30 days postoperatively.
Results
At day 14, statistically significant smaller wounds were observed with digital image analysis in the ozone group as compared with the control group (p = 0.034). However, intergroup comparison of the remaining wound area evaluated by the clinician using the H2O2 method did not reveal any significant differences (p > 0.05). Nonetheless, according to Bland-Altman analysis, the lower and upper limits showed a moderate agreement between the two measurement methods. The mean VAS sores exhibiting postoperative discomfort was observed to be significantly higher in the control group compared with the laser group (p = 0.002) and ozone group (p < 0.001) at day 7.
Conclusions
Adjunctive ozone therapy could have a significantly beneficial effect on the acceleration of palatal wound healing following FGG procedures. Both PBM and ozone treatment modalities reduced postoperative discomfort as compared with spontaneous healing.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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