Sulforaphane Normalizes Intestinal Flora and Enhances Gut Barrier in Mice with BBN-Induced Bladder Cancer
He C, Huang L, Lei P, Liu X, Li B, Shan Y
Molecular nutrition & food research · 69 citations
How it was studied
- Design
- Animal study (classified by our AI screen)
- Studied in
- Animals
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- University or hospital
- University of Glasgow
- Government
- National Natural Science Foundation of China
- University or hospital
- Heilongjiang University of Chinese Medicine
- Grants
- National Natural Science Foundation of China (81773427)
Based on 3 listed funder(s).
Publication
- Published
- 2018-10-10 · Mol Nutr Food Res · vol. 62 · issue 24 · p. e1800427
- Publisher
- Wiley
- Cited
- 81 citations · more than 89% of similar papers · 2.2× the field average
- References
- 56 works
- Access
- Paywalled
- Research areas
- Genomics, phytochemicals, and oxidative stress · Gut microbiota and health · Immune cells in cancer
- Keywords
- Sulforaphane, Bladder cancer, Gut flora, Cruciferous vegetables, Tight junction, Inflammation, Dysbiosis, Cancer, Colorectal cancer, Cancer research, Immune system, Carcinogenesis, Nitrosamine, Immunology, Medicine, Chemistry, Internal medicine, Carcinogen, Biochemistry
- MeSH
- caco-2 cells, animals, mice, inbred c57bl, humans, butyric acid, isothiocyanates, butylhydroxybutylnitrosamine, sulfoxides, immunoglobulin a, secretory, anticarcinogenic agents, interleukin-6, male, urinary bladder neoplasms, tight junction proteins, gastrointestinal microbiome
6 authors
From CN
- Canxia HeHarbin Institute of Technology
- Lei HuangHarbin Institute of Technology
- Lei PengHarbin Institute of Technology
- Xiaodong LiuHarbin Institute of Technology
- Bao‐Long Li · correspondingHeilongjiang University of Chinese Medicine
- Yujuan Shan · correspondingHarbin Institute of Technology
Abstract
Scope
Gut microbiota imbalance, inflammation, and gut barrier deficiency play an important role in carcinogenesis. Sulforaphane (SFN), an isothiocyanate found in cruciferous vegetables, has been proven to be highly effective in inhibiting cancer. The objective of this study is to investigate the potential roles of the gut microbiota in the inhibition of BBN-induced bladder cancer by SFN.
Methods and results
N-butyl-N-(4-hydroxybutyl)-nitrosamine is used to induce bladder cancer in male C57BL/6 mice, with or without SFN for 23 weeks. SFN ameliorates the histological changes characteristic of bladder cancer, resulting in fewer submucosal capillaries. SFN normalizes gut microbiota dysbiosis in mice with BBN-induced bladder cancer with a significant increase in Bacteroides fragilis and Clostridium cluster I. SFN also increases butyric acid levels in the mouse colon, and repairs the injury to the mucosal epithelium of the colon and cecum through the upregulation of the expression of tight junction proteins and GLP2. SFN greatly decreases the release of cytokines (IL-6) and secretory immunoglobulin A in the mice with bladder cancer.
Conclusion
These results suggest that SFN protects against chemical-induced bladder cancer through normalizing the composition of gut microbiota and repairing the physiological destruction of the gut barrier, as well as decreasing inflammation and the immune response.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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