Effects of Meditation and Music-Listening on Blood Biomarkers of Cellular Aging and Alzheimer's Disease in Adults with Subjective Cognitive Decline: An Exploratory Randomized Clinical Trial
Innes KE, Selfe TK, Brundage K, Montgomery C, Wen S, Kandati S, Bowles H, Khalsa DS, Huysmans Z
Journal of Alzheimer's disease : JAD · 66 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- National Institute of General Medical Sciences
- Government
- NIGMS NIH HHS
- Grants
- National Institute of General Medical Sciences (P20 GM109098); National Institute of General Medical Sciences (U54-GM-104942)
Based on 2 listed funder(s).
Publication
- Published
- 2018-10-11 · J Alzheimers Dis · vol. 66 · issue 3 · pp. 947–970
- Publisher
- IOS Press
- Cited
- 106 citations · more than 96% of similar papers · 5.8× the field average
- Impact
- Top 10% most cited in its field
- References
- 151 works
- Access
- Open access (repository copy)
- Research areas
- Music Therapy and Health · Biofield Effects and Biophysics · Cancer-related cognitive impairment studies
- Keywords
- Meditation, Cognition, Active listening, Psychology, Disease, Randomized controlled trial, Cognitive reserve, Cognitive decline, Alzheimer's disease, Clinical psychology, Audiology, Medicine, Dementia, Cognitive impairment, Neuroscience, Psychotherapist, Internal medicine
- MeSH
- leukocytes, mononuclear, telomere, humans, alzheimer disease, telomerase, treatment outcome, meditation, stress, psychological, cognition, sleep, quality of life, music, aged, aged, 80 and over, middle aged, female, male, amyloid beta-peptides, biomarkers, cognitive dysfunction, cellular senescence
9 authors
From US
- Kim E. InnesWest Virginia University
- Terry Kit SelfeWest Virginia University; University of Florida Health Science Center
- Kathleen M. BrundageWest Virginia University Hospitals
- Caitlin J. MontgomeryWest Virginia University
- Sijin WenWest Virginia University Hospitals
- Sahiti KandatiWest Virginia University
Abstract
Background
Telomere length (TL), telomerase activity (TA), and plasma amyloid-β (Aβ) levels have emerged as possible predictors of cognitive decline and dementia.
Objective
To assess the: 1) effects of two 12-week relaxation programs on TL, TA, and Aβ levels in adults with subjective cognitive decline; and 2) relationship of biomarker changes to those in cognitive function, psychosocial status, and quality of life (QOL).
Methods
Participants were randomized to a 12-week Kirtan Kriya meditation (KK) or music listening (ML) program and asked to practice 12 minutes/day. Plasma Aβ(38/40/42) and peripheral blood mononuclear cell TL and TA were measured at baseline and 3 months. Cognition, stress, sleep, mood, and QOL were assessed at baseline, 3 months, and 6 months.
Results
Baseline blood samples were available for 53 participants (25 KK, 28 ML). The KK group showed significantly greater increases in Aβ40 than the ML group. TA rose in both groups, although increases were significant only among those with higher practice adherence and lower baseline TA. Changes in both TL and TA varied by their baseline values, with greater increases among participants with values ≤50th percentile (ps-interaction <0.006). Both groups improved in cognitive and psychosocial status (ps ≤0.05), with improvements in stress, mood, and QOL greater in the KK group. Rising Aβ levels were correlated with gains in cognitive function, mood, sleep, and QOL at both 3 and 6 months, associations that were particularly pronounced in the KK group. Increases in TL and TA were also correlated with improvements in certain cognitive and psychosocial measures.
Conclusion
Practice of simple mind-body therapies may alter plasma Aβ levels, TL, and TA. Biomarker increases were associated with improvements in cognitive function, sleep, mood, and QOL, suggesting potential functional relationships.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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