The effects of caffeine intake on weight loss: a systematic review and dos-response meta-analysis of randomized controlled trials
Tabrizi R, Saneei P, Lankarani KB, Akbari M, Kolahdooz F, Esmaillzadeh A, Nadi-Ravandi S, Mazoochi M, Asemi Z
Critical reviews in food science and nutrition · 77 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- University or hospital
- Shiraz University of Medical Sciences
Based on 1 listed funder(s).
Publication
- Published
- 2018-10-18 · Crit Rev Food Sci Nutr · vol. 59 · issue 16 · pp. 2688–2696
- Publisher
- Taylor & Francis
- Cited
- 122 citations · more than 60% of similar papers · 0.6× the field average
- References
- 38 works
- Access
- Paywalled
- Research areas
- Coffee research and impacts · Diet and metabolism studies · Eating Disorders and Behaviors
- Keywords
- Meta-analysis, Randomized controlled trial, Weight loss, Caffeine, Medicine, Food science, Internal medicine, Biology, Obesity
- MeSH
- humans, weight loss, caffeine, central nervous system stimulants, dose-response relationship, drug
9 authors
From IR, CA
- Reza TabriziShiraz University of Medical Sciences
- Parvane SaneeiIsfahan University of Medical Sciences
- Kamran Bagheri LankaraniShiraz University of Medical Sciences
- Maryam AkbariShiraz University of Medical Sciences
- Fariba KolahdoozUniversity of Alberta
- Ahmad EsmaillzadehIsfahan University of Medical Sciences; Tehran University of Medical Sciences
Abstract
This systematic review and meta-analysis of randomized controlled trials (RCTs) was performed to summarize the effect of caffeine intake on weight loss. We searched the following databases until November 2017: MEDLINE, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials. The relevant data were extracted and assessed for quality of the studies according to the Cochrane risk of bias tool. We estimated an intake-status regression coefficient (Beta) for each primary study and estimated the overall pooled Beta and SE using random effects meta-analysis on a double-log scale. Heterogeneity between studies was assessed by the Cochran Q statistic and I-squared tests (I2). Thirteen RCTs with 606 participants were included in the meta-analyses. The overall pooled Beta for the effect of caffeine intake was 0.29 (95%CI: 0.19, 0.40; Q = 124.5, I2 = 91.2%) for weigh, 0.23 (95%CI: 0.09, 0.36; Q = 71.0, I2 = 93.0%) for BMI, and 0.36 (95% CI: 0.24, 0.48; Q = 167.36, I2 = 94.0%) for fat mass. For every doubling in caffeine intake, the mean reduction in weight, BMI, and fat mass increased 2 Beta-fold (20.29 = 1.22, 20.23 = 1.17, and 20.36 = 1.28), which corresponding to 22, 17, and 28 percent, respectively. Overall, the current meta-analysis demonstrated that caffeine intake might promote weight, BMI and body fat reduction.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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