Funded in part by Amgen, AstraZeneca, Sanofi
A higher ratio of refined grain to whole grain is associated with a greater likelihood of chronic kidney disease: a population-based study
Mazidi M, Katsiki N, Mikhailidis DP, Banach M
The British journal of nutrition · 17 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cross-sectional study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Industry funded
- Company
- Amgen
- Company
- AstraZeneca
- Company
- Sanofi
Based on 3 listed funder(s).
Publication
- Published
- 2018-10-30 · Br J Nutr · vol. 121 · issue 11 · pp. 1294–1302
- Publisher
- Cambridge University Press
- Cited
- 22 citations · more than 69% of similar papers · 0.7× the field average
- References
- 66 works
- Access
- Free to read
- Research areas
- Food composition and properties · Nutritional Studies and Diet · Nutrition and Health in Aging
- Keywords
- Kidney disease, Population, Disease, Medicine, Biology, Animal science, Internal medicine, Environmental health
- MeSH
- humans, albuminuria, creatinine, uric acid, albumins, kidney function tests, glomerular filtration rate, diet, nutrition surveys, prevalence, logistic models, risk factors, cross-sectional studies, adult, aged, middle aged, female, male, renal insufficiency, chronic, edible grain, whole grains
4 authors
From CN, GR, GB, PL
- Mohsen Mazidi · correspondingChinese Academy of Sciences; Institute of Genetics and Developmental Biology
- Niki KatsikiAristotle University of Thessaloniki; Ippokrateio General Hospital of Thessaloniki
- Dimitri P. MikhailidisThe Royal Free Hospital; University College London
- Maciej BanachMedical University of Lodz; Polish Mother’s Memorial Hospital Research Institute; University of Zielona Góra
Abstract
A growing number of studies suggest that diet and renal function are related. However, little is known about the link between both whole grain (WG) and refined grain (RG) consumption and kidney function parameters. Thus, we investigated the association of WG and RG with urinary albumin to creatinine ratio (ACR) and prevalent chronic kidney disease (CKD). Data from participants of the National Health and Nutrition Examination Surveys (NHANES) from 2005 to 2010 were collected. Estimated glomerular filtration rate (eGFR) was calculated by the CKD Epidemiology Collaboration equation. Survey design and sample weights were taken into consideration for statistical analyses. Finally, we included 16 325 participants from NHANES, 6·9 % of whom had prevalent CKD. In models adjusted for age, sex, race, fasting blood glucose, blood pressure, adiposity, hypertension and diabetes status, mean eGFR significantly increased across increasing quartiles of WG (Q1: 88·2 v. Q4: 95·4 ml/min per 1·73 m2, P<0·001), whereas it significantly decreased across increasing quartiles of RG (Q1: 97·2 v. Q4: 88·4 ml/min per 1·73 m2, P<0·001). Furthermore, serum uric acid levels and ACR significantly decreased across quartiles of WG (both P<0·001). In multivariable-adjusted logistic regression models, the likelihood of prevalent CKD was 21 % lower in the highest WG quartile compared with the lowest one. In conclusion, our results shed light on the beneficial impact of WG on kidney function and CKD, whereas RG is adversely associated with eGFR.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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