The Effect of Whole-Body Cryotherapy at Different Temperatures on Proinflammatory Cytokines, Oxidative Stress Parameters, and Disease Activity in Patients with Ankylosing Spondylitis
Straburzyńska-Lupa A, Kasprzak MP, Romanowski MW, Kwaśniewska A, Romanowski W, Iskra M, Rutkowski R
Oxidative medicine and cellular longevity · 17 citations
How it was studied
- Design
- Controlled clinical trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- University or hospital
- Akademia Wychowania Fizycznego im. Eugeniusza Piaseckiego w Poznaniu
- University or hospital
- Poznan University of Physical Education
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2018-01-01 · Oxid Med Cell Longev · vol. 2018 · issue 1 · p. 2157496
- Publisher
- Hindawi Publishing Corporation
- Cited
- 36 citations · more than 88% of similar papers · 2.4× the field average
- References
- 46 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Spondyloarthritis Studies and Treatments · Exercise and Physiological Responses · Rheumatoid Arthritis Research and Therapies
- Keywords
- Ankylosing spondylitis, Proinflammatory cytokine, Oxidative stress, Cryotherapy, Disease, Inflammation, Medicine, Immunology, Spondylitis, Internal medicine, Surgery
- MeSH
- humans, spondylitis, ankylosing, inflammation mediators, cytokines, cryotherapy, temperature, oxidative stress, middle aged, female, male
7 authors
From PL, HU
- Anna Straburzyńska‐Lupa · correspondingUniversity of Physical Culture in Kraków; Hungarian University of Sports Science
- Magdalena Paulina KasprzakPoznan University of Medical Sciences
- Mateusz Wojciech RomanowskiPoznan University of Medical Sciences
- Anna Kwaśniewska
- Wojciech Romanowski
- María Pilar IskraPoznan University of Medical Sciences
Abstract
Purpose
Patients with ankylosing spondylitis (AS) have increased production of proinflammatory cytokines, increased oxidants, and decreased antioxidant capacity. The aim of this study was to determine the effect of whole-body cryotherapy (WBC) at -110°C and -60°C, on disease activity, selected proinflammatory cytokines, and oxidative stress in patients with AS.
Methods
Sixty-five patients with AS were recruited to one of three study procedures: WBC at -110°C, -60°C, or exercise therapy (non-WBC). The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Ankylosing Spondylitis Disease Activity Score (ASDAS-CRP), concentration of C-reactive protein (CRP), and the concentrations of interleukin 8 and 17 (IL-8, IL-17) were measured at the beginning of the study and at the end of the intervention. The concentration of thiobarbituric acid reactive substances (TBARS), as a lipid peroxidation result, and total antioxidant status, an antioxidant organism potential, were measured.
Results
All the studied groups showed significantly decreased posttherapy disease activity expressed as a function of the BASDAI, ASDAS-CRP, and the IL-8 concentration. We found that the TBARS concentration after therapy was significantly increased in the WBC at -110°C group. A comparison of the therapeutic effects between the treatment groups showed a significantly lower BASDAI after therapy in the WBC at -110°C group compared to the non-WBC group.
Conclusion
WBC at -110°C had a positive effect on lowering AS clinical activity as measured by the BASDAI.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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