Whole grain diet reduces systemic inflammation: A meta-analysis of 9 randomized trials
Xu Y, Wan Q, Feng J, Du L, Li K, Zhou Y
Medicine · 43 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Mechanisms only
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
- Grants
- National Natural Science Foundation of China (30901427)
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2018-10-01 · Medicine (Baltimore) · vol. 97 · issue 43 · p. e12995
- Publisher
- Wolters Kluwer
- Cited
- 54 citations · more than 91% of similar papers · 3.0× the field average
- Impact
- Top 10% most cited in its field
- References
- 67 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Food composition and properties · Nutritional Studies and Diet · Celiac Disease Research and Management
- Keywords
- Medicine, Meta-analysis, Strictly standardized mean difference, Confidence interval, Cochrane Library, Observational study, Internal medicine, Randomized controlled trial, Subgroup analysis, Whole grains, Systemic inflammation, C-reactive protein, MEDLINE, Gastroenterology, Inflammation, Food science
- MeSH
- humans, inflammation, diet, randomized controlled trials as topic, whole grains
6 authors
From CN, GB
- Yujie Xu
- Qianyi Wan
- Jinhua FengSichuan University; West China Hospital of Sichuan University
- Liang DuCochrane
- Ka Li · correspondingSichuan University; West China Hospital of Sichuan University
- Yong Hong Zhou · corresponding
Abstract
Backgrounds
Observational studies had suggested an inverse association between whole grain consumption and concentration of inflammatory markers, but evidence from interventional studies was inconsistent. Therefore, we conducted a meta-analysis of randomized trials to have a better understanding of this issue.
Methods
This study has been registered in PROSPERO (ID: CRD42018096533). We searched PubMed, Web of Science, Embase, Medline, and Cochrane Library for articles focusing on the topic from inception to 1 January, 2018. Summary standardized mean difference (SMD) and 95% confidence interval (CI) were calculated by using either random effect model or fixed effect model according to the heterogeneity of included studies. Subgroup analysis was also performed.
Results
Totally 9 randomized trials included 838 participants were identified. In a pooled analysis of all studies, consumption of whole grains had an inverse association with inflammatory markers (SMD 0.16, 95% CI, 0.02-0.30), including C-reactive protein (CRP), Interleukin-6 (IL-6), Tumor necrosis factor-α (TNF-α), Interleukin-1β (IL-1β). Specific analyses for CRP and IL-6 yielded that whole grain diet was related with a significant decrease in the concentration of CRP (SMD 0.29, 95% CI, 0.08-0.50) and IL-6 (SMD 0.19, 95% CI, 0.03-0.36).
Conclusions
The evidence suggested that citizens could benefit from increased whole grain intake for reducing systemic inflammation. Further well-designed studies are required to investigate the mechanism under the appearance.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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