The association between blood concentration of 25- hydroxyvitamin D and sarcopenia: a meta-analysis
Luo J, Quan Z, Lin S, Cui L
Asia Pacific journal of clinical nutrition · 26 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2019-09-16 · Asia Pac J Clin Nutr · vol. 27 · issue 6 · pp. 1258–1270
- Publisher
- National Institutes of Health
- Cited
- 36 citations · more than 89% of similar papers · 2.3× the field average
- References
- 0 works
- Access
- Paywalled
- Research areas
- Vitamin D Research Studies · Nutrition, Genetics, and Disease · Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- Sarcopenia, Medicine, Confidence interval, Internal medicine, Prospective cohort study, Meta-analysis, Cohort study, Confounding, Subgroup analysis, Gastroenterology
- MeSH
- humans, vitamin d, sensitivity and specificity, case-control studies, prospective studies, cross-sectional studies, aged, aged, 80 and over, middle aged, female, male, sarcopenia, observational studies as topic
4 authors
From CN
- Jing LuoQingdao University
- Zhenyu QuanYanbian University
- Song LinQingdao University
- Lianhua CuiQingdao University
Abstract
Background and objectives
Associations between blood 25-hydroxyvitamin D (25(OH)D) concentration and sarcopenia remain controversial; thus, this meta-analysis was conducted to explore the relationship between blood 25(OH)D concentration and sarcopenia.
Design
We searched the PubMed and EMBASE databases for relevant published observational studies that investigated blood 25(OH)D concentration and sarcopenia up to June 2017.We then investigated data from these studies that compared blood 25(OH)D concentrations between the sarcopenia and healthy control groups. A random-effect model was used to calculate the pooled weighted mean difference (WMD) of blood 25(OH)D concentration with a 95% confidence interval (95% CI).
Results
Twelve studies (eight cross-sectional, two matched case-control, and two prospective cohort studies) with a total of 22,590 individuals were included. Sarcopenic individuals had lower blood 25(OH)D concentrations than healthy controls (WMD=-2.14, 95% CI: -2.81--1.48; I2=74.6%). Subgroup analysis showed that the methods of assessing both blood 25(OH)D concentrations and sarcopenia might be sources of heterogeneity, and further showed that studies excluding obese individuals and different sarcopenia assessment criteria enhanced the relationship. Sensitivity analysis by one-study-removed confirmed the robustness of these results.
Conclusions
Our study shows that sarcopenic adults have lower blood 25(OH)D concentrations. Further high-quality large-scale prospective cohort studies are needed to confirm these findings.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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