Red meat intake, CYP2E1 and PPARγ polymorphisms, and colorectal cancer risk
Kim NH, Seol JE, Kim J, Lee BH, Hwang DY, Jeong J, Lee HJ, Ahn YO, Kim DH, Lee JE
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 8 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Case-control study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2018-11-26 · Eur J Cancer Prev · vol. 28 · issue 4 · pp. 304–310
- Publisher
- Lippincott Williams & Wilkins
- Cited
- 10 citations · more than 54% of similar papers · 0.3× the field average
- References
- 25 works
- Access
- Paywalled
- Research areas
- Peroxisome Proliferator-Activated Receptors · Cancer, Lipids, and Metabolism · Metabolomics and Mass Spectrometry Studies
- Keywords
- Odds ratio, Internal medicine, Red meat, Allele, Medicine, Colorectal cancer, CYP2E1, Logistic regression, Gastroenterology, Case-control study, Genotype, Biology, Endocrinology, Oncology, Genetics, Cancer, Metabolism, Pathology, Cytochrome P450, Gene
- MeSH
- humans, colorectal neoplasms, genetic predisposition to disease, cytochrome p-450 cyp2e1, ppar gamma, diet surveys, risk factors, case-control studies, polymorphism, single nucleotide, adult, aged, middle aged, female, male, republic of korea, red meat
10 authors
From KR, NL, US
- Na-Hui KimSookmyung Women's University; Food & Nutrition
- Ju Eun SeolSookmyung Women's University; Food & Nutrition
- Jeongseon KimNational Cancer Center
- Bong-Hwa Lee · correspondingHallym University
- Dae–Yong HwangKonkuk University Medical Center
- Jinyoung JeongHallym University
Abstract
The association between red meat intake and colorectal cancer (CRC) may be modulated by genetic polymorphisms of cytochrome P450 2E1 (CYP2E1), a key enzyme in the metabolism of nitrosamines, and peroxisome proliferator-activated receptor gamma (PPARγ), a transcription factor involved in adipogenesis and lipid and glucose metabolism. We conducted a case-control study of 971 patients with CRC and 658 controls who were admitted to two university hospitals between 1995 and 2004 in Seoul, Korea. Participants were asked about red meat intake by using a validated food frequency questionnaire. Polymorphisms of CYP2E1 (rs3813867) and PPARγ (rs1801282 or rs3856806) were identified using the TaqMan assay. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) using multivariable logistic regression models. We found that the association between red meat and CRC varied by CYP2E1 polymorphisms; ORs (95% CIs) for at least five or more vs. less than one time/week of red meat intake were 2.77 (1.23-6.25) among individuals with C alleles of CYP2E1 and 0.89 (0.51-1.54) among individuals with the GG allele (Pinteraction=0.05). Compared with those individuals with the CC allele, increasing risk of CRC with increasing red meat intake was more pronounced among individuals with T alleles of PPARγC161T (rs3856806), but the association was not significant. Our data provide evidence that East Asians with the variant type of CYP2E1 may have high susceptibility to development of CRC risk.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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