Impact of Acute Dietary Nitrate Supplementation during Exercise in Hypertensive Women
Caldwell JT, Sutterfield SL, Post HK, Craig JC, Baumfalk DR, Copp SW, Ade CJ
Medicine and science in sports and exercise · 11 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2018-12-07 · Med Sci Sports Exerc · vol. 51 · issue 5 · pp. 1014–1021
- Publisher
- Lippincott Williams & Wilkins
- Cited
- 25 citations · more than 81% of similar papers · 1.2× the field average
- References
- 56 works
- Access
- Paywalled
- Research areas
- Cardiovascular and exercise physiology · Cardiovascular Health and Disease Prevention · Nitric Oxide and Endothelin Effects
- Keywords
- Medicine, Blood pressure, Forearm, Placebo, Brachial artery, Heart rate, Cardiology, Internal medicine, Blood flow, Diastole, Sphygmomanometer, Dietary Nitrate, Hemodynamics, Anesthesia, Surgery, Nitrate, Chemistry, Pathology, Nitrite
- MeSH
- forearm, brachial artery, humans, beta vulgaris, hypertension, nitrates, nitrites, hand strength, exercise, cross-over studies, double-blind method, postmenopause, blood pressure, exercise tolerance, dietary supplements, middle aged, female, hemodynamics, fruit and vegetable juices
7 authors
From US
- Jacob T. CaldwellKansas State University
- Shelbi L. SutterfieldKansas State University
- Hunter K. PostKansas State University
- Jesse C. CraigKansas State University
- Dryden Ray BaumfalkKansas State University
- Steven W. CoppKansas State University
Abstract
Introduction
the aim of the current investigation was to examine if dietary nitrate supplementation would improve vascular control in hypertensive postmenopausal women (PMW). We tested the hypotheses that acute dietary nitrate supplementation would 1) significantly decrease arterial blood pressure (BP) at rest and during exercise, 2) increase limb blood flow during steady-state (SS) exercise, and 3) improve functional sympatholysis during SS exercise.
Methods
Ten hypertensive PMW underwent a randomized, double-blind, placebo-controlled trial with a nitrate-rich (NR) or nitrate-poor (NP) supplement. Beat-by-beat BP and heart rate were recorded throughout the trial on the nonexercising limb. Forearm blood flow was measured via ultrasonography on the brachial artery of the exercising limb. All patients performed a resting cold pressor test (CPT) (2 min) and then 7 min of submaximal handgrip exercise with a CPT applied during minutes 5-7.
Results
SS systolic (NR, 170 ± 7; NP, 171 ± 37 mm Hg), diastolic (NR, 89 ± 2; NP, 92 ± 2 mm Hg), and mean arterial (NR, 121 ± 4; NP, 123 ± 2 mm Hg) pressures were not different between NP and NR treatment conditions (P > 0.05). During SS exercise, forearm blood flow (NR, 189 ± 8; NP, 218 ± 8 mL·min; P = 0.03) in the NR treatment was significantly lower compared with NP. When the CPT was applied during minutes 6-7 of exercise, forearm vascular conductance was reduced by 15% in the NR condition, but only 7% in the NR condition.
Conclusions
In summary, an acute NR supplement improved functional sympatholysis by ~50% versus an NP placebo condition. Improvements in functional sympatholysis may have important implications regarding exercise tolerance in hypertensive PMW.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.