Metabolic Profiling of High Egg Consumption and the Associated Lower Risk of Type 2 Diabetes in Middle-Aged Finnish Men
Noerman S, Kärkkäinen O, Mattsson A, Paananen J, Lehtonen M, Nurmi T, Tuomainen TP, Voutilainen S, Hanhineva K, Virtanen JK
Molecular nutrition & food research · 16 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Case-control study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Government
- Academy of Finland
- Nonprofit
- Suomen Kulttuurirahasto
- Nonprofit
- Juho Vainion Säätiö
- University or hospital
- Kuopion Yliopistollinen Sairaala
- University or hospital
- Biocenter Finland
- Nonprofit
- Pohjois-Savon Rahasto
- Government
- Terveyden Tutkimuksen Toimikunta
- Grants
- Terveyden Tutkimuksen Toimikunta (283454); Terveyden Tutkimuksen Toimikunta (305396); Suomen Kulttuurirahasto (65171618); Terveyden Tutkimuksen Toimikunta (277986); Kuopion Yliopistollinen Sairaala (VTR 510RA17)
Based on 7 listed funder(s).
Publication
- Published
- 2018-12-13 · Mol Nutr Food Res · vol. 63 · issue 5 · p. e1800605
- Publisher
- Wiley
- Cited
- 20 citations · more than 90% of similar papers · 2.6× the field average
- References
- 47 works
- Access
- Paywalled
- Research areas
- Nutritional Studies and Diet · Metabolomics and Mass Spectrometry Studies · Antioxidant Activity and Oxidative Stress
- Keywords
- Type 2 diabetes, Medicine, Diabetes mellitus, Odds ratio, Prospective cohort study, Internal medicine, Risk factor, Lower risk, Population, Endocrinology, Physiology, Confidence interval
- MeSH
- humans, diabetes mellitus, type 2, incidence, risk factors, case-control studies, eggs, adult, middle aged, finland, male, biomarkers
10 authors
From FI
- Stefania NoermanUniversity of Eastern Finland
- Olli K. KärkkäinenUniversity of Eastern Finland
- Anton MattssonUniversity of Eastern Finland; Aalto University
- Jussi PaananenUniversity of Eastern Finland
- Marko LehtonenUniversity of Eastern Finland; Biocenter Finland
- Tarja NurmiUniversity of Eastern Finland
Abstract
Scope
Higher egg intake was previously associated with a lower risk of developing type 2 diabetes (T2D) in the prospective, population-based Kuopio Ischaemic Heart Disease Risk Factor Study (KIHD) in eastern Finland. Potential compounds that can explain this association are explored using nontargeted LC-MS-based metabolic profiling.
Methods and results
Two hundred and thirty-nine baseline serum samples from the KIHD are analyzed in four groups: subjects with higher (mean intake one egg per day) or lower (mean intake two eggs per week) egg intake who developed T2D (cases) or remained heatlhy (controls) during the mean follow-up of 19.3 years. Different serum profiles of subjects who had either higher or lower egg intakes, and of those who developed type 2 diabetes or remained healthy, are observed. The higher baseline tyrosine level predicts higher odds of T2D (OR 1.94; 95% CI 1.45, 2.60; p < 0.001; FDR 0.023) along with an unknown hexose-containing compound (OR 2.13; 95% CI 1.57, 2.88; p < 0.001; FDR 0.005). Certain predominant metabolites in T2D cases are correlated positively with ones in the lower-egg-intake group and negatively with ones in the higher-egg-intake group.
Conclusion
Our current findings may underline some potential metabolites that can explain how egg intake is associated with a lower risk of T2D.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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