Serum 25-Hydroxyvitamin D Concentrations and Major Depression: A Mendelian Randomization Study
Michaëlsson K, Melhus H, Larsson SC
Nutrients · 41 citations
How it was studied
- Design
- Case-control study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- Government
- Vetenskapsrådet
Based on 1 listed funder(s).
Publication
- Published
- 2018-12-15 · Nutrients · vol. 10 · issue 12 · p. 1987
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 46 citations · more than 96% of similar papers · 4.4× the field average
- Impact
- Top 10% most cited in its field
- References
- 10 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Vitamin D Research Studies · Eating Disorders and Behaviors · Asthma and respiratory diseases
- Keywords
- Mendelian randomization, Vitamin D and neurology, Depression (economics), Confidence interval, Odds ratio, vitamin D deficiency, Medicine, Internal medicine, Physiology, Endocrinology, Genetics, Bioinformatics, Biology, Gene, Genotype, Genetic variants
- MeSH
- humans, vitamin d deficiency, vitamin d, odds ratio, case-control studies, polymorphism, single nucleotide, mendelian randomization analysis, major depressive disorder
3 authors
From SE
- Karl Michaëlsson · correspondingUppsala University
- Håkan MelhusUppsala University
- Susanna C. Larsson · correspondingUppsala University; Karolinska Institutet
Abstract
Whether vitamin D insufficiency is a contributing cause of depression remains unclear. We assessed whether serum 25-hydroxyvitamin D (S-25OHD) concentrations, the clinical marker of vitamin D status, were associated with major depression using Mendelian randomization. We used summary statistics data for six single-nucleotide polymorphisms significantly associated with S-25OHD concentrations in the Study of Underlying Genetic Determinants of Vitamin D and Highly Related Traits (SUNLIGHT) consortium and the corresponding data for major depression (n = 59,851 cases and 113,154 controls) from the Psychiatric Genomics Consortium. Genetically predicted S-25OHD concentrations were not associated with major depression. The odds ratio per genetically predicted one standard deviation decrease in S-25OHD concentrations was 1.02 (95% confidence interval 0.97⁻1.08; p = 0.44). The results of this study indicate that genetically lowered S-25OHD concentrations are not associated with increased risk of developing major depression.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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