Low Levels of Branched Chain Amino Acids, Eicosapentaenoic Acid and Micronutrients Are Associated with Low Muscle Mass, Strength and Function in Community-Dwelling Older Adults
Ter Borg S, Luiking YC, van Helvoort A, Boirie Y, Schols JMGA, de Groot CPGM
The journal of nutrition, health & aging · 63 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cross-sectional study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Industry funded
- Nonprofit
- Alexander von Humboldt-Stiftung
- Authors
- At least one author declares a financial tie to industry
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2018-10-13 · J Nutr Health Aging · vol. 23 · issue 1 · pp. 27–34
- Publisher
- Springer Science+Business Media
- Cited
- 70 citations · more than 91% of similar papers · 2.7× the field average
- Impact
- Top 10% most cited in its field
- References
- 42 works
- Access
- Open access (hybrid journal) · CC-BY-NC-ND
- Research areas
- Nutrition and Health in Aging · Muscle metabolism and nutrition · Frailty in Older Adults
- Keywords
- Sarcopenia, Eicosapentaenoic acid, Internal medicine, Medicine, Homocysteine, Endocrinology, Docosahexaenoic acid, Skeletal muscle, Micronutrient, Amino acid, Polyunsaturated fatty acid, Chemistry, Fatty acid, Biochemistry
- MeSH
- muscle, skeletal, humans, eicosapentaenoic acid, micronutrients, amino acids, branched-chain, cross-sectional studies, aged, aged, 80 and over, female, male, sarcopenia, independent living
6 authors
From FR, NL, US, NP
- Sovianne ter BorgDanone (France); Nutricia Research (Netherlands); Danone Nutricia Research (Netherlands)
- Yvette C. Luiking · correspondingTexas A&M University System; Danone (France); Nutricia Research (Netherlands); Danone Nutricia Research (Netherlands); Texas A&M University
- Ardy van HelvoortMaastricht University; Danone (France); Nutricia Research (Netherlands); Danone Nutricia Research (Netherlands)
- Yves BoirieUnité de Nutrition Humaine; Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement; University of Clermont Auvergne; Centre de Recherche en Nutrition Humaine Rhône-Alpes; Centre Hospitalier Universitaire de Clermont-Ferrand; Centre de Recherche en Nutrition Humaine d'Auvergne
- Jos M. G. A. ScholsMaastricht University; Department of Health Services
- C.P.G.M. de GrootWageningen University & Research
Abstract
Background
Sarcopenia, the age-related decrease in muscle mass and function can result in adverse health outcomes and subsequent loss of independence. Inadequate nutrition is an important contributor to the aetiology of sarcopenia, and dietary strategies are studied to prevent or delay this geriatric syndrome.
Objective
The present study investigated whether there is an association between biochemical nutrient status markers, muscle parameters and sarcopenia in community-dwelling older adults.
Design
Data from the cross-sectional Maastricht Sarcopenia study (MaSS) were used, in which skeletal muscle index (SMI), 4 meter gait speed, 5 times chair stand and handgrip strength were assessed among older adults (n=227). Sarcopenia was defined following the algorithm of the European Working Group on Sarcopenia in Older People. Fasted blood samples were analyses on amino acids levels, RBC phospholipid profile, 25-hydroxyvitamin D (25(OH)D), α-tocopherol, magnesium and homocysteine were determined in fasted blood levels. Generalized linear modelling and logistic regression were used for data analysis.
Results
Lower blood levels of essential amino acids (EAA), total branched-chain amino acids (BCAA) and leucine were associated with lower SMI (P<0.001), strength (P<0.001) and longer time to complete the chair stand (P<0.05), whereas no association was found for total amino acids (TAA). Lower levels of eicosapentaenoic acid (EPA), 25(OH)D and homocysteine were associated with lower muscle parameter values (P<0.05). No significant associations were found for SFA, MUFA, PUFA, n-3 and n-6 fatty acids, docosahexaenoic acid (DHA), α-tocopherol-cholesterol ratio and magnesium. Sarcopenia was more frequent among those with lower levels of leucine, BCAA, EAA, EPA, 25(OH)D and higher levels of homocysteine (P<0.05). Age and BMI were identified as relevant covariates. A robust association was only found for lower gait speed and lower 25(OH)D levels.
Conclusion
Compromised muscle parameters are associated with low blood values of specific amino acids, fatty acids, vitamin D and high homocysteine.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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