Acute heat stress reduces biomarkers of endothelial activation but not macro- or microvascular dysfunction in cervical spinal cord injury
Coombs GB, Barak OF, Phillips AA, Mijacika T, Sarafis ZK, Lee AHX, Squair JW, Bammert TD, DeSouza NM, Gagnon D, Krassioukov AV, Dujic Z, DeSouza CA, Ainslie PN
American journal of physiology. Heart and circulatory physiology · 29 citations
How it was studied
- Design
- Controlled clinical trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- Canada Research Chairs
- Unclassified
- International Collaboration on Repair Discoveries
- Government
- National Institutes of Health
- University or hospital
- Research Services, University of Calgary
- Government
- National Heart, Lung, and Blood Institute
- Government
- NHLBI NIH HHS
- Government
- HHS | National Institutes of Health (NIH)
- Government
- Canada Research Chairs (Chaires de recherche du Canada)
- Unclassified
- Blusson Integrated Cures Partnership
- Grants
- National Heart, Lung, and Blood Institute (R01 HL077450); National Heart, Lung, and Blood Institute (R01HL107715); Canada Research Chairs (F16-02798); National Institutes of Health (HL077450); National Institutes of Health (HL107715)
Based on 9 listed funder(s).
Publication
- Published
- 2018-12-21 · Am J Physiol Heart Circ Physiol · vol. 316 · issue 3 · pp. H722–H733
- Publisher
- American Physical Society
- Cited
- 32 citations · more than 84% of similar papers · 1.7× the field average
- References
- 73 works
- Access
- Free to read
- Research areas
- Spinal Cord Injury Research · Cardiovascular Health and Disease Prevention · Aortic Disease and Treatment Approaches
- Keywords
- Medicine, Reactive hyperemia, Endothelial dysfunction, Brachial artery, Spinal cord injury, Cardiology, Internal medicine, Anesthesia, CD31, Spinal cord, Blood flow, Blood pressure, Angiogenesis
- MeSH
- cervical vertebrae, arteries, endothelium, vascular, humans, spinal cord injuries, e-selectin, hyperthermia, induced, hemorheology, heat-shock response, adult, middle aged, female, male, microvessels, biomarkers
14 authors
From CA, RS, HR, US
- Geoff B. Coombs · correspondingUniversity of British Columbia; University of British Columbia, Okanagan Campus; Okanagan University College
- Otto F. BarakUniversity of Novi Sad
- Aaron Alexander PhillipsUniversity of Calgary; Libin Cardiovascular Institute of Alberta
- Tanja MijačikaUniversity of Split
- Zoe K. SarafisUniversity of British Columbia; International Collaboration On Repair Discoveries
- Amanda H. X. LeeUniversity of British Columbia; International Collaboration On Repair Discoveries
Abstract
Cardiovascular diseases (CVD) are highly prevalent in spinal cord injury (SCI), and peripheral vascular dysfunction might be a contributing factor. Recent evidence demonstrates that exposure to heat stress can improve vascular function and reduce the risk of CVD in uninjured populations. We therefore aimed to examine the extent of vascular dysfunction in SCI and the acute effects of passive heating. Fifteen participants with cervical SCI and 15 uninjured control (CON) participants underwent ultrasound assessments of vascular function and venous blood sampling for biomarkers of endothelial activation (i.e., CD62e+) and apoptosis (i.e., CD31+/42b-) before and after a 60-min exposure to lower limb hot water immersion (40°C). In SCI, macrovascular endothelial function was reduced in the brachial artery [SCI: 4.8 (3.2)% vs. CON: 7.6 (3.4)%, P = 0.04] but not the femoral artery [SCI: 3.7 (2.6)% vs. CON: 4.0 (2.1)%, P = 0.70]. Microvascular function, via reactive hyperemia, was ~40% lower in SCI versus CON in both the femoral and brachial arteries ( P + were elevated in SCI versus CON [SCI: 152 (106) microparticles/µl vs. CON: 58 (24) microparticles/µl, P + concentrations in SCI to levels similar to CON ( P = 0.05). These data highlight the potential of acute heating to provide a safe and practical strategy to improve vascular function in SCI. The chronic effects of controlled heating warrant long-term testing. NEW & NOTEWORTHY Individuals with cervical level spinal cord injury exhibit selectively lower flow-mediated dilation in the brachial but not femoral artery, whereas peak reactive hyperemia was lower in both arteries compared with uninjured controls. After 60 min of lower limb hot water immersion, femoral artery blood flow and shear patterns were acutely improved in both groups. Elevated biomarkers of endothelial activation in the spinal cord injury group decreased with heating, but these biomarkers remained unchanged in controls.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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