Dietary nitrate improves muscle microvascular reactivity and lowers blood pressure at rest and during isometric exercise in untreated hypertensives
Zafeiridis A, Triantafyllou A, Papadopoulos S, Koletsos N, Touplikioti P, Zafeiridis AS, Gkaliagkousi E, Dipla K, Douma S
Microcirculation (New York, N.Y. : 1994) · 20 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2018-12-26 · Microcirculation · vol. 26 · issue 3 · p. e12525
- Publisher
- Wiley
- Cited
- 22 citations · more than 85% of similar papers · 1.8× the field average
- References
- 61 works
- Access
- Paywalled
- Research areas
- Cardiovascular and exercise physiology · Nitric Oxide and Endothelin Effects · Exercise and Physiological Responses
- Keywords
- Medicine, Isometric exercise, Cardiology, Arterial stiffness, Pulse wave velocity, Internal medicine, Hemoglobin, Blood pressure, Anesthesia
- MeSH
- humans, hypertension, nitrates, hand strength, exercise, double-blind method, blood pressure, vascular resistance, dietary supplements, adult, middle aged, female, male, hemodynamics, vascular stiffness, pulse wave analysis
11 authors
From GR
- Andreas ZafeiridisAristotle University of Thessaloniki; Papageorgiou General Hospital; General Hospital of Serres
- Andreas Zafeiridis · correspondingAristotle University of Thessaloniki; Papageorgiou General Hospital; General Hospital of Serres
- Areti TriantafyllouAristotle University of Thessaloniki; Papageorgiou General Hospital
- Stavros PapadopoulosAristotle University of Thessaloniki; Papageorgiou General Hospital; General Hospital of Serres
- Nikolaos KoletsosTheageneio General Hospital; Papageorgiou General Hospital
- Panagiota TouplikiotiAristotle University of Thessaloniki; Theageneio General Hospital; Papageorgiou General Hospital
Abstract
Objective
This double-blind, cross-over study examined in drug-naïve hypertensives the effects of a single dose of dietary nitrate (beetroot juice, BRJ) on (a) office/ambulatory BP and arterial stiffness, (b) muscle microvascular function, and (c) hemodynamic responses and cardiovagal baroreceptor sensitivity (cBRS) at rest and during isometric exercise.
Methods
Eighteen untreated hypertensives (44.0 ± 2.6 years) consumed randomly, a nitrate-rich (8.1 mmol-BRJnitrate ) and a nitrate-depleted (BRJplacebo ) BRJ. Office BP and pulse wave velocity were assessed before/after BRJ. An occlusion-reperfusion maneuver with continuous monitoring of muscle oxygenated hemoglobin (O2 Hb) and total hemoglobin (tHb), via NIRS, followed. Participants performed submaximal isometric handgrip with beat-by-beat monitoring of hemodynamics and cBRS. Ambulatory BP assessment followed.
Results
During reperfusion, following arterial occlusion, the magnitude and rate of muscle microvascular reoxygenation (O2 Hb) and red blood cell content (tHb) were higher in BRJnitrate vs BRJplacebo (P nitrate vs BRJplacebo (P nitrate vs BRJplacebo (P < 0.01-0.05), with no differences in cBRS.
Conclusions
In drug-naïve hypertensives, a single dose of BRJ induces (a) short-term reductions in resting/ambulatory BP, (b) acute improvements in muscle microvascular function, and (c) attenuation in BP and peripheral resistance responses during isometric exercise.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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