An 8-week diet high in cereal fiber and coffee but free of red meat does not improve beta-cell function in patients with type 2 diabetes mellitus: a randomized controlled trial
Karusheva Y, Kunstein L, Bierwagen A, Nowotny B, Kabisch S, Groener JB, Fleitmann AK, Herder C, Pacini G, Strassburger K, Häring HU, Nawroth PP, Pfeiffer AFH, Burkart V, Müssig K, Roden M, Szendroedi J
Nutrition & metabolism · 3 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Government
- Bundesministerium für Bildung und Forschung
- Government
- Bundesministerium für Gesundheit
- Government
- Brandenburger Staatsministerium für Wissenschaft, Forschung und Kultur
- University or hospital
- Helmholtz Association
- Government
- Ministerium für Wissenschaft, Forschung und Kultur
Based on 5 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2018-12-01 · Nutr Metab (Lond) · vol. 15 · issue 1 · p. 90
- Publisher
- BioMed Central
- Cited
- 6 citations · more than 62% of similar papers · 0.4× the field average
- References
- 41 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Diet and metabolism studies · Biochemical Analysis and Sensing Techniques · Coffee research and impacts
- Keywords
- Medicine, Red meat, Internal medicine, Type 2 diabetes, Insulin, Diabetes mellitus, Randomized controlled trial, Meal, Type 2 Diabetes Mellitus, Endocrinology, Gastroenterology
17 authors
From DE, US, IT
- Yanislava KarushevaDeutsches Diabetes-Zentrum e.V.; German Center for Diabetes Research; Heinrich Heine University Düsseldorf
- Lejla KunsteinDeutsches Diabetes-Zentrum e.V.; German Center for Diabetes Research; Heinrich Heine University Düsseldorf
- Alessandra BierwagenDeutsches Diabetes-Zentrum e.V.; German Center for Diabetes Research; Heinrich Heine University Düsseldorf
- Bettina NowotnyDeutsches Diabetes-Zentrum e.V.; German Center for Diabetes Research; Heinrich Heine University Düsseldorf
- Stefan KabischDeutsches Diabetes-Zentrum e.V.; German Center for Diabetes Research; German Institute of Human Nutrition; Heinrich Heine University Düsseldorf; Franklin University; Charité - Universitätsmedizin Berlin
- Jan Benedikt GroenerHeidelberg University; University Hospital Heidelberg
Abstract
Background
Higher dietary intake of fibers and coffee, but lower red meat intake is associated with reduced risk for type 2 diabetes in epidemiological studies. We hypothesized that a calorie-restricted diet, which is high in fiber and coffee, but free of red meat, improves beta-cell function in patients with T2D.
Methods
In a randomized parallel-group pilot trial, obese type 2 diabetes patients were randomly allocated to consume either a diet high in cereal fiber and coffee, but free of red meat (n = 17) (L-RISK) or a diet low in fiber, free of coffee but high in red meat (n = 20) (H-RISK) for 8 weeks. Insulin secretion was assessed from glucagon stimulation tests (GST) and mixed-meal tolerance tests (MMTT) before and after dietary intervention.
Results
Both diets resulted in comparable reduction of fasting concentrations of insulin (H-RISK -28% vs. L-RISK -32%, both p both p p p p < 0.01). However, GST and MMTT showed no differences in insulin secretion after intervention.
Conclusions
Calorie restriction independent of the intake of fiber, coffee or meat failed to improve beta-cell function, but improved GIP secretion in obese patients with type 2 diabetes.
Trial registration
Registration at Clinicaltrials.gov, Identifier number: NCT01409330, Registered 4 August 2011 - Retrospectively registered.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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