Respiratory mechanics and cerebral blood flow during heat-induced hyperventilation and its voluntary suppression in passively heated humans
Tsuji B, Hoshi Y, Honda Y, Fujii N, Sasaki Y, Cheung SS, Kondo N, Nishiyasu T
Physiological reports · 16 citations
How it was studied
- Design
- Controlled clinical trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Nonprofit
- Uehara Memorial Foundation
- Government
- Ministry of Education, Culture, Sports, Science and Technology
- Government
- Japan Society for the Promotion of Science
- Grants
- Japan Society for the Promotion of Science (17H00876); Japan Society for the Promotion of Science (15H03069); Ministry of Education, Culture, Sports, Science and Technology (17H00876)
Based on 3 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2019-01-01 · Physiol Rep · vol. 7 · issue 1 · p. e13967
- Publisher
- Wiley
- Cited
- 18 citations · more than 68% of similar papers · 0.8× the field average
- References
- 46 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Climate Change and Health Impacts · Thermoregulation and physiological responses · Thermal Regulation in Medicine
- Keywords
- Hyperventilation, Medicine, Work of breathing, Anesthesia, Ventilation (architecture), Breathing, Respiratory physiology, Respiratory system, Cerebral blood flow, Tidal volume, Respiratory rate, Cardiology, Internal medicine, Blood pressure, Heart rate, Physics
- MeSH
- humans, hyperventilation, work of breathing, body temperature, hyperthermia, induced, cerebrovascular circulation, respiratory mechanics, adult, male, breath holding, physical conditioning, human
8 authors
From JP, CA
- Bun TsujiPrefectural University of Hiroshima; University of Tsukuba; Tsukuba University of Technology; Tsukuba International University
- Yuta HoshiUniversity of Tsukuba; Tsukuba University of Technology; Tsukuba International University
- Yasushi HondaUniversity of Tsukuba; Tsukuba University of Technology; Tsukuba International University
- Naoto FujiiUniversity of Tsukuba; Tsukuba University of Technology; Tsukuba International University
- Yosuke SasakiUniversity of Tsukuba; Tsukuba University of Technology; Tsukuba International University
- Stephen S. CheungBrock University
Abstract
We investigated whether heat-induced hyperventilation can be voluntarily prevented, and, if so, how this modulates respiratory mechanics and cerebral blood flow in resting heated humans. In two separate trials, 10 healthy men were passively heated using lower body hot-water immersion and a water-perfused garment covering their upper body (both 41°C) until esophageal temperature (Tes ) reached 39°C or volitional termination. In each trial, participants breathed normally (normal-breathing) or voluntarily controlled minute ventilation (VE ) at a level equivalent to that observed after 5 min of heating (controlled-breathing). Respiratory gases, middle cerebral artery blood velocity (MCAV), work of breathing, and end-expiratory and inspiratory lung volumes were measured. During normal-breathing, VE increased as Tes rose above 38.0 ± 0.3°C, whereas controlled-breathing diminished the increase in VE (VE at Tes = 38.6°C: 25.6 ± 5.9 and 11.9 ± 1.3 L min-1 during normal- and controlled-breathing, respectively, P 2 pressure and MCAV decreased with rising Tes , but controlled-breathing diminished these reductions (at Tes = 38.6°C, 24.7 ± 5.0 vs. 39.5 ± 2.8 mmHg; 44.9 ± 5.9 vs. 60.2 ± 6.3 cm sec-1 , both P E (P -1 , respectively, at heating termination, P = 0.013). End-expiratory and inspiratory lung volumes did not differ between trials (P = 0.25 and 0.71, respectively). These results suggest that during passive heating at rest, heat-induced hyperventilation increases the work of breathing without affecting end-expiratory lung volume, and that voluntary control of breathing can nearly abolish this hyperventilation, thereby diminishing hypocapnia, cerebral hypoperfusion, and increased work of breathing.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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