A Plant-Based Meal Increases Gastrointestinal Hormones and Satiety More Than an Energy- and Macronutrient-Matched Processed-Meat Meal in T2D, Obese, and Healthy Men: A Three-Group Randomized Crossover Study
Klementova M, Thieme L, Haluzik M, Pavlovicova R, Hill M, Pelikanova T, Kahleova H
Nutrients · 46 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food provided by researchers
Who paid for it
- Funding
- Independent funding
- Government
- Ministerstvo Zdravotnictví Ceské Republiky
- Grants
- Ministerstvo Zdravotnictví Ceské Republiky (AZV15-27338A)
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2019-01-12 · Nutrients · vol. 11 · issue 1 · p. 157
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 67 citations · more than 98% of similar papers · 8.0× the field average
- Impact
- Top 10% most cited in its field
- References
- 46 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Eating Disorders and Behaviors · Consumer Attitudes and Food Labeling · Diet and metabolism studies
- Keywords
- Peptide YY, Postprandial, Amylin, Meal, Internal medicine, Crossover study, Endocrinology, Population, Incretin, Appetite, Medicine, Type 2 diabetes, Glucagon-like peptide-1, Gastric inhibitory polypeptide, Hormone, Gastrointestinal hormone, Insulin, Glucagon, Diabetes mellitus, Peptide hormone, Neuropeptide Y receptor, Placebo, Neuropeptide
- MeSH
- humans, diabetes mellitus, type 2, obesity, cholesterol, gastrointestinal hormones, insulin, dietary carbohydrates, blood glucose, dietary fats, triglycerides, dietary proteins, body mass index, cross-over studies, satiation, diet, vegetarian, postprandial period, meat products, adult, aged, middle aged, male, meals, glycated hemoglobin
7 authors
From CZ, US
- Marta KlementováInstitute of Clinical and Experimental Medicine
- Lenka ThiemeInstitute of Clinical and Experimental Medicine
- Martin Haluzı́kInstitute of Clinical and Experimental Medicine
- Renáta PavlovičováInstitute of Clinical and Experimental Medicine
- Martin HillInstitute of Endocrinology
- Terezie PelikánováInstitute of Clinical and Experimental Medicine
Abstract
Gastrointestinal hormones are involved in regulation of glucose metabolism and satiety. We tested the acute effect of meal composition on these hormones in three population groups. A randomized crossover design was used to examine the effects of two energy- and macronutrient-matched meals: a processed-meat and cheese (M-meal) and a vegan meal with tofu (V-meal) on gastrointestinal hormones, and satiety in men with type 2 diabetes (T2D, n = 20), obese men (O, n = 20), and healthy men (H, n = 20). Plasma concentrations of glucagon-like peptide -1 (GLP-1), amylin, and peptide YY (PYY) were determined at 0, 30, 60, 120 and 180 min. Visual analogue scale was used to assess satiety. We used repeated-measures Analysis of variance (ANOVA) for statistical analysis. Postprandial secretion of GLP-1 increased after the V-meal in T2D (by 30.5%; 95%CI 21.2 to 40.7%; p p = 0.01). Postprandial plasma concentrations of amylin increased in in all groups after the V-meal: by 15.7% in T2D (95%CI 11.8 to 19.6%; p p = 0.03); and by 13.8% in H (95%CI 8.4 to 19.5%; p p = 0.03). Satiety was greater in all participants after the V-meal: by 9% in T2D (95%CI 4.4 to 13.6%; p = 0.004); by 18.7% in O (95%CI 12.8 to 24.6%; p p < 0.001). Our results indicate there is an increase in gut hormones and satiety, following consumption of a single plant-based meal with tofu when compared with an energy- and macronutrient-matched processed-meat meat and cheese meal, in healthy, obese and diabetic men.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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