25 Hydroxyvitamin D Levels are Negatively and Independently Associated with Fat Mass in a Cohort of Healthy Overweight and Obese Subjects
De Pergola G, Martino T, Zupo R, Caccavo D, Pecorella C, Paradiso S, Silvestris F, Triggiani V
Endocrine, metabolic & immune disorders drug targets · 34 citations
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2019-01-22 · Endocr Metab Immune Disord Drug Targets · vol. 19 · issue 6 · pp. 838–844
- Publisher
- Bentham Science Publishers
- Cited
- 49 citations · more than 94% of similar papers · 3.9× the field average
- Impact
- Top 10% most cited in its field
- References
- 27 works
- Access
- Free to read
- Research areas
- Vitamin D Research Studies · Adipokines, Inflammation, and Metabolic Diseases · Cancer Risks and Factors
- Keywords
- Internal medicine, Medicine, Endocrinology, Overweight, Body mass index, Insulin resistance, Obesity, Blood pressure, Waist, Vitamin D and neurology, Cohort, Metabolic syndrome, Body fat percentage
- MeSH
- adipose tissue, humans, obesity, vitamin d, organ size, cohort studies, body composition, adolescent, adult, aged, middle aged, female, male, adiposity, overweight, young adult, obesity, metabolically benign
8 authors
From IT
- Giovanni De Pergola · correspondingUniversity of Bari Aldo Moro
- Tommaso MartinoUniversity of Bari Aldo Moro
- Roberta ZupoUniversity of Bari Aldo Moro
- Domenico CaccavoUniversity of Bari Aldo Moro
- Claudio PecorellaUniversity of Bari Aldo Moro
- Silvia ParadisoUniversity of Bari Aldo Moro
Abstract
Background
Obesity is associated with lower serum vitamin D (25(OH)D) levels through several mechanisms. The aim of the study was to examine the possibility of a negative association between fat mass and 25(OH)D levels in a cohort of otherwise healthy overweight and obese subjects, independently of age, sex, blood pressure levels and anthropometric and metabolic parameters.
Materials and methods
147 overweight and obese subjects (106 women and 41 men), aged between 18 and 69 years, were enrolled into the study. All of them did not show any clinically evident metabolic or chronic diseases (i.e. hypertension, diabetes mellitus, renal failure, etc.) and did not use any kind of drug. Serum fasting levels of 25(OH)D, insulin, glucose, uric acid and lipids (triglycerides, total, HDL and LDL cholesterol) were measured. The season in which the blood samples were collected was autumn. Insulin resistance was assessed by using the Homeostasis Model Assessment (HOMA-IR). Body composition parameters (Fat Mass [FM], Fat Free Mass [FFM], body cell mass [BCM], Total Body Water [TBW]) were measured by electrical Bioimpedance Analysis (BIA). Lastly, demographic, anthropometric and clinical parameters (age, Body Mass Index [BMI], Waist Circumference [WC], Systolic (SBP) and Diastolic (DBP) blood pressure) were also assessed.
Results
25(OH)D levels were significantly and negatively correlated with BMI (P <0.001), WC (P <0.01), DBP (P <0.05), insulin (P <0.001), HOMA-IR (P <0.01), triglycerides (P <0.01), and fat mass (P <0.001). A multivariate regression analysis was performed by considering 25(OH)D levels as the dependent variable and sex, waist circumference, fat mass, DBP, triglycerides, and insulin (or HOMAIR) as the independent ones, and 25(OH)D levels maintained a significant and independent relationship only with fat mass (negative) (P <0.01).
Conclusion
This study clearly shows that 25(OH)D circulating levels are progressively lower with the increase of fat mass, independently of sex, body fat distribution, blood pressure and insulin and metabolic parameters. These data strongly show that adipose tissue accumulation per se is absolutely the main factor responsible factor for lower 25(OH)D levels in obese subjects, possibly through sequestration of fat soluble 25(OH)D in fat mass.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC).
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