Effect of Fermented Fish Oil on Fine Particulate Matter-Induced Skin Aging
Hyun YJ, Piao MJ, Kang KA, Zhen AX, Madushan Fernando PDS, Kang HK, Ahn YS, Hyun JW
Marine drugs · 36 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- In vitro/mechanistic study (classified by our AI screen)
- Studied in
- Cells or lab samples
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Independent funding
- Government
- National Research Foundation
- Government
- Ministry of Science, ICT and Future Planning
- Government
- National Research Foundation of Korea
- University or hospital
- Basic Research Laboratory
- Grants
- Ministry of Science, ICT and Future Planning (NRF-2017R1A4A1014512); National Research Foundation of Korea (NRF-2017R1A4A1014512); National Research Foundation of Korea (2017R1A4A1014512); National Research Foundation of Korea (NRF-2016H1D5A1908786); Ministry of Science, ICT and Future Planning (2017R1A4A1014512)
Based on 4 listed funder(s).
Publication
- Published
- 2019-01-18 · Mar Drugs · vol. 17 · issue 1 · p. 61
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 48 citations · more than 90% of similar papers · 2.9× the field average
- Impact
- Top 10% most cited in its field
- References
- 31 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Air Quality and Health Impacts · Skin Protection and Aging · Indoor Air Quality and Microbial Exposure
- Keywords
- Matrix metalloproteinase, Skin Aging, Intracellular, Chemistry, Reactive oxygen species, Fish oil, MAPK/ERK pathway, Activator (genetics), Cell biology, Biochemistry, Biology, Kinase, Fish <Actinopterygii>, Medicine, Gene, Fishery
- MeSH
- cell line, keratinocytes, skin, animals, perciformes, humans, calcium, reactive oxygen species, matrix metalloproteinases, fish oils, transcription factor ap-1, antioxidants, air pollutants, map kinase signaling system, fermentation, oxidative stress, skin aging, particulate matter
8 authors
From KR
- Yu Jae HyunJeju National University
- Mei Jing PiaoJeju National University
- Kyoung Ah KangJeju National University
- Ao Xuan ZhenJeju National University
- Pincha Devage Sameera Madushan FernandoJeju National University
- Hee Kyoung KangJeju National University
Abstract
Skin is exposed to various harmful environmental factors such as air pollution, which includes different types of particulate matter (PM). Atmospheric PM has harmful effects on humans through increasing the generation of reactive oxygen species (ROS), which have been reported to promote skin aging via the induction of matrix metalloproteinases (MMPs), which in turn can cause the degradation of collagen. In this study, we investigated the effect of fermented fish oil (FFO) derived from mackerel on fine PM (particles with a diameter 2.5)-induced skin aging in human keratinocytes. We found that FFO inhibited the PM2.5-induced generation of intracellular ROS and MMPs, including MMP-1, MMP-2, and MMP-9. In addition, FFO significantly abrogated the elevation of intracellular Ca2+ levels in PM2.5-treated cells and was also found to block the PM2.5-induced mitogen-activated protein kinase/activator protein 1 (MAPK/AP-1) pathway. In conclusion, FFO has an anti-aging effect on PM2.5-induced aging in human keratinocytes.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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