Association of whole grain, refined grain, and cereal consumption with gastric cancer risk: A meta-analysis of observational studies
Xu Y, Yang J, Du L, Li K, Zhou Y
Food science & nutrition · 30 citations
How it was studied
- Design
- Meta-analysis (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
- Government
- National Nature Science Foundation of China
- Government
- The Sichuan Provincial Science and Technology Support Project
- Industry group
- Chinese Medical Board Grant on Evidence-based Medicine
- Grants
- National Natural Science Foundation of China (30901427)
Based on 4 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2018-11-11 · Food Sci Nutr · vol. 7 · issue 1 · pp. 256–265
- Publisher
- Wiley
- Cited
- 49 citations · more than 95% of similar papers · 4.5× the field average
- Impact
- Top 10% most cited in its field
- References
- 65 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Helicobacter pylori-related gastroenterology studies · Gastric Cancer Management and Outcomes · Colorectal Cancer Screening and Detection
- Keywords
- Observational study, Whole grains, Meta-analysis, Association (psychology), Medicine, Consumption (sociology), Food science, Environmental health, Internal medicine, Psychology, Biology, Sociology
5 authors
From CN, GB
- Yujie XuSichuan University; West China Hospital of Sichuan University
- Jie YangSichuan University; West China Hospital of Sichuan University
- Liang DuCochrane
- Ka Li · correspondingSichuan University; West China Hospital of Sichuan University
- Yong Zhou · correspondingSichuan University; West China Hospital of Sichuan University
Abstract
Many studies have analyzed the relationship between cereal, whole, or refined grain and the risk of gastric cancer (GC) and have yielded mixed results. Therefore, we performed a meta-analysis of observational studies to summarize the available evidence on this topic. Databases such as PubMed, EMBASE, Web of Science, MEDLINE, and the Cochrane Library were searched for studies focusing on these associations from inception to October 2017. Summary odd ratios (OR) and 95% confidence intervals (CI) were calculated by using either a random- or fixed-effect model according to the between-studies heterogeneity. Subgroup analysis was also performed. In total, eleven studies that included 530,176 participants were identified. In a pooled analysis of all studies, cereal exposure was not associated with GC risk (OR, 1.11, 95%CI, 0.85-1.36). Specific analyses indicated that whole grain consumption was associated with decreased GC risk (OR, 0.61, 95%CI, 0.40-0.83) and that refined grain consumption was associated with increased GC risk (OR, 1.65, 95%CI, 1.36-1.94). Higher whole grain and lower refined grain intake but not cereal consumption reduces GC risk. This study has been registered at ClinicalTrials.gov (ID: NCT03419663).
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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