Effects of magnesium supplementation on carotid intima-media thickness and metabolic profiles in diabetic haemodialysis patients: a randomised, double-blind, placebo-controlled trial
Talari HR, Zakizade M, Soleimani A, Bahmani F, Ghaderi A, Mirhosseini N, Eslahi M, Babadi M, Mansournia MA, Asemi Z
The British journal of nutrition · 38 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- University or hospital
- Kashan University of Medical Sciences
Based on 1 listed funder(s).
Publication
- Published
- 2019-02-11 · Br J Nutr · vol. 121 · issue 7 · pp. 809–817
- Publisher
- Cambridge University Press
- Cited
- 46 citations · more than 91% of similar papers · 3.2× the field average
- Impact
- Top 10% most cited in its field
- References
- 69 works
- Access
- Free to read
- Research areas
- Magnesium in Health and Disease · Cardiovascular Health and Disease Prevention · Therapeutic Uses of Natural Elements
- Keywords
- Intima-media thickness, Placebo, Medicine, Double blind, Magnesium, Randomized controlled trial, Internal medicine, Diabetes mellitus, Placebo-controlled study, Cardiology, Endocrinology, Carotid arteries, Chemistry
- MeSH
- humans, diabetes mellitus, insulin resistance, magnesium, malondialdehyde, cholesterol, insulin, blood glucose, c-reactive protein, antioxidants, treatment outcome, renal dialysis, double-blind method, dietary supplements, middle aged, female, male, metabolome, carotid intima-media thickness
10 authors
From IR, CA
- Hamid Reza TalariKashan University of Medical Sciences
- Mehrafrouz ZakizadeKashan University of Medical Sciences
- Alireza SoleimaniKashan University of Medical Sciences
- Fereshteh BahmaniKashan University of Medical Sciences
- Amir GhaderiKashan University of Medical Sciences
- Naghmeh Zahra MirhosseiniUniversity of Saskatchewan
Abstract
This study evaluated the effects of Mg administration on carotid intima-media thickness (CIMT), glycaemic control and markers of cardio-metabolic risk in diabetic haemodialysis (HD) patients. This randomised, double-blind, placebo-controlled clinical trial was conducted in fifty-four diabetic HD patients. Participants were randomly divided into two groups to take either 250 mg/d Mg as magnesium oxide (n 27) or placebo (n 27) for 24 weeks. Mg supplementation resulted in a significant reduction in mean (P<0·001) and maximum levels of left CIMT (P=0·02) and mean levels of right CIMT (P=0·004) compared with the placebo. In addition, taking Mg supplements significantly reduced serum insulin levels (β=-9·42 pmol/l; 95% CI -14·94, -3·90; P=0·001), homoeostasis model of assessment-insulin resistance (β=-0·56; 95 % CI -0·89, -0·24; P=0·001) and HbA1c (β=-0·74 %; 95 % CI -1·10, -0·39; P<0·001) and significantly increased the quantitative insulin sensitivity check index (β=0·008; 95 % CI 0·002, 0·01; P=0·002) compared with the placebo. In addition, Mg administration led to a significant reduction in serum total cholesterol (β=-0·30 mmol/l; 95% CI -0·56, -0·04; P=0·02), LDL-cholesterol (β=-0·29 mmol/l; 95% CI -0·52, -0·05; P=0·01), high-sensitivity C-reactive protein (hs-CRP) (P<0·001) and plasma malondialdehyde (MDA) (P=0·04) and a significant rise in plasma total antioxidant capacity (TAC) levels (P<0·001) compared with the placebo. Overall, we found that taking Mg for 24 weeks by diabetic HD patients significantly improved mean and maximum levels of left and mean levels of right CIMT, insulin metabolism, HbA1c, total cholesterol and LDL-cholesterol, hs-CRP, TAC and MDA levels.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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